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Development and Physical Characterization of a Periodontal Bioadhesive Gel of Metronidazole Publisher Pubmed



Varshosaz J1 ; Tavakoli N1 ; Saidian S1
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutics, Sch. of Pharm./Pharmaceut. Sciences, Isfahan Univ. of Medical Sciences, Isfahan, P.O. Box 81745-359, Iran

Source: Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents Published:2002


Abstract

To develop a localized drug delivery system that offers prolonged administration of metronidazole into the periodontal pocket, muc-coadhesive gel formulations containing 5% w/w metronidazole were prepared using the bioadhesive polymers: carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, polyvinylpirrolidone, and carbopol. Increased concentrations of the polymers decreased the drug release rate and enhanced syringeability, yield value, and adhesiveness but decreased the spreadability. The bioadhesive properties of the gels were affected by pH and Ca2+ concentration. The gel containing 20% hydroxyethylcellulose, 20% polyvinylpirrolidone, and 1% carbopol exhibited zero-order drug release kinetics and suitable physical properties for drug delivery to the periodontal pocket.
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