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Optic Neuritis Following Covid-19 Vaccination: Case Series and Review of the Literature; [Nevrite Optique Apres Vaccination Contre La Covid-19: Serie De Cas Et Revue De La Litterature] Publisher Pubmed



Etemadifar M1 ; Nouri H2, 3, 4 ; Abtahi SH5, 6 ; Bathaei R2, 4 ; Mardi R4 ; Salari M7 ; Dehghani A8 ; Panahi Seifabad M4, 8 ; Jannesari A2, 4
Authors
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Authors Affiliations
  1. 1. Department of Neurosurgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Alzahra Research Institute, Alzahra University Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Ophthalmic Research Center, Research Institute for Ophthalmology, Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Ophthalmic Research Center, Research Institute for Ophthalmology, Vision Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Ophthalmology, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Isfahan Eye Research Center, Department of ophthalmology, Isfahan University of medical sciences, Isfahan, Iran

Source: Journal Francais d'Ophtalmologie Published:2024


Abstract

Objective: To review cases of optic neuritis after COVID-19 vaccination and add similar cases to the literature. Methods: Thorough PubMed and Scopus searches were conducted, and data from studies describing optic neuritis after COVID-19 vaccination were extracted, tabulated, pooled, and reviewed. Results: We present 6 cases of optic neuritis following COVID-19 vaccination. Our literature search yielded 48 similar cases. All 54 cases were divided into 3 groups with respect to their serostatus: (1) double-seronegative or unknown serostatus optic neuritis cases, (2) myelin oligodendrocyte glycoprotein (MOG)-associated optic neuritis cases, and (3) aquaporin-4-associated optic neuritis cases. Data from each group were separately pooled and reviewed. While the most frequent vaccine among the anti-AQP4+ subgroup was BNT162b2 (Pfizer-BioNTech) (2/3), recombinant vaccines, e.g., AZD122 and Ad26.Cov2.s were mostly injected in the other subgroups (23/51). No significant gender inclination was seen among different subgroups. The mean interval from vaccination to symptom onset was less than one month in all subgroups; symptom manifestations mainly occurred after the first dose (28/54). Almost all cases showed improvement after steroid therapy ± plasma exchange (52/54). Conclusion: Despite having rare side effects such as optic neuritis, vaccination remains our most helpful protection against SARS-CoV-2. Nevertheless, larger studies are needed to ascertain the pathophysiology of such adverse effects. Likewise, the association between COVID-19 vaccination and optic neuritis warrants further investigation. © 2024 Elsevier Masson SAS
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