Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Diagnosis and Classification of Optic Neuritis Publisher Pubmed



Petzold A1, 2, 3 ; Fraser CL4 ; Abegg M5 ; Alroughani R6 ; Alshowaeir D7 ; Alvarenga R8 ; Andris C9 ; Asgari N10 ; Barnett Y11 ; Battistella R12 ; Behbehani R13 ; Berger T14 ; Bikbov MM15 ; Biotti D112 Show All Authors
Authors
  1. Petzold A1, 2, 3
  2. Fraser CL4
  3. Abegg M5
  4. Alroughani R6
  5. Alshowaeir D7
  6. Alvarenga R8
  7. Andris C9
  8. Asgari N10
  9. Barnett Y11
  10. Battistella R12
  11. Behbehani R13
  12. Berger T14
  13. Bikbov MM15
  14. Biotti D112
  15. Biousse V16
  16. Boschi A17, 18
  17. Brazdil M19, 20
  18. Brezhnev A21
  19. Calabresi PA22
  20. Cordonnier M23
  21. Costello F24
  22. Cruz FM25
  23. Cunha LP26
  24. Daoudi S27
  25. Deschamps R28
  26. De Seze J29
  27. Diem R30
  28. Etemadifar M31
  29. Floresrivera J32
  30. Fonseca P33, 34
  31. Frederiksen J35, 36
  32. Frohman E37
  33. Frohman T37
  34. Tilikete CF38, 39
  35. Fujihara K40
  36. Galvez A41
  37. Gouider R42
  38. Gracia F43, 44
  39. Grigoriadis N45
  40. Guajardo JM46
  41. Habek M47, 48
  42. Hawlina M49
  43. Martinezlapiscina EH50, 51
  44. Hooker J52
  45. Hor JY53
  46. Howlett W54
  47. Huanglink Y55
  48. Idrissova Z56
  49. Illes Z57
  50. Jancic J58
  51. Jindahra P59
  52. Karussis D61
  53. Kerty E62
  54. Kim HJ63
  55. Lagreze W64
  56. Leocani L65
  57. Levin N66
  58. Liskova P67
  59. Liu Y68
  60. Maiga Y69
  61. Marignier R70
  62. Mcguigan C71, 72
  63. Meira D73
  64. Merle H74
  65. Monteiro MLR75
  66. Moodley A76
  67. Moura F77
  68. Munoz S78
  69. Mustafa S79
  70. Nakashima I80
  71. Noval S81
  72. Oehninger C82
  73. Ogun O83
  74. Omoti A84
  75. Pandit L85
  76. Paul F86
  77. Rebolleda G87
  78. Reddel S88
  79. Rejdak K89
  80. Rejdak R90
  81. Rodriguezmorales AJ91
  82. Rougier MB92
  83. Sa MJ93
  84. Sanchezdalmau B94
  85. Saylor D95
  86. Shatriah I96
  87. Siva A97
  88. Stiebelkalish H60
  89. Szatmary G98
  90. Ta L99
  91. Tenembaum S100
  92. Tran H101
  93. Trufanov Y102
  94. Van Pesch V103, 104
  95. Wang AG105
  96. Wattjes MP106
  97. Willoughby E107
  98. Zakaria M108
  99. Zvornicanin J109
  100. Balcer L110
  101. Plant GT111
Show Affiliations
Authors Affiliations
  1. 1. The National Hospital for Neurology and Neurosurgery, University College London, London, United Kingdom
  2. 2. Moorfields Eye Hospital, London, United Kingdom
  3. 3. Neuro-ophthalmology Expert Centre, Amsterdam University Medical Center, Amsterdam, Netherlands
  4. 4. Department of Ophthalmology, University of Sydney, Sydney, NSW, Australia
  5. 5. Department of Ophthalmology, University of Bern, Bern, Switzerland
  6. 6. Division of Neurology, Department of Medicine, Al-Amiri Hospital, Kuwait City, Kuwait
  7. 7. Department of Ophthalmology, King Saud University, Riyadh, Saudi Arabia
  8. 8. Department of Neurology, Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rio de Janeiro, Brazil
  9. 9. Department of Ophthalmology, University Hospital Liege, University of Liege, Liege, Belgium
  10. 10. Department of Neurology, Slagelse and Institute of Regional Health Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
  11. 11. Department of Neuroradiology, St Vincent's Hospital, Sydney, NSW, Australia
  12. 12. Department of Neuro-Ophthalmology, University of Sao Paulo, Sao Paulo, Brazil
  13. 13. Neuro-Ophthalmology Unit, Ibn Sina Hospital, Kuwait City, Kuwait
  14. 14. Department of Neurology, Medical University of Vienna, Vienna, Austria
  15. 15. Ufa Eye Research Institute, Ufa, Russian Federation
  16. 16. Neuro-Ophthalmology Unit, Emory Eye Center, Emory University, Atlanta, GA, United States
  17. 17. Department of Head and Neck, Universite Catholique de Louvain, Brussels, Belgium
  18. 18. Department of Ophthalmology, Cliniques Universitaires Saint Luc, Brusseles, Belgium
  19. 19. Department of Neurology, Masaryk University, Brno, Czech Republic
  20. 20. St Anne's University Hospital, Brno, Czech Republic
  21. 21. Department of Ophthalmology, Kursk State Medical University, Kursk, Russian Federation
  22. 22. The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States
  23. 23. Department of Ophthalmology, Universite Libre de Bruxelles, Bruxelles, Belgium
  24. 24. Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
  25. 25. College of Medicine, University of the Philippines—Philippine General Hospital, Manila, Philippines
  26. 26. Surgery Department of Juiz de Fora Medical School, Federal University of Juiz de Fora, Juiz de Fora, Brazil
  27. 27. Department of Neurology, University Mouloud Mammeri de Ttizi Ouzou, Ttizi Ouzou, Algeria
  28. 28. Department of Neurology, Hospital Foundation Adolphe de Rothschild, Paris, France
  29. 29. Department of Neurology, Hopitaux Universitaires Strasbourg, Strasbourg, France
  30. 30. Department of Neurology, University Clinic Heidelberg, Heidelberg, Germany
  31. 31. Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan, Iran
  32. 32. Universidad Nacional Autonoma de Mexico, Instituto Nacional de Neurologia y Neurocirugia, Centro Medico ABC, Mexico City, Mexico
  33. 33. Department of Ophthalmology, Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal
  34. 34. Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Coimbra, Portugal
  35. 35. Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
  36. 36. Department of Neurology, Copenhagen University Hospital, Copenhagen, Denmark
  37. 37. Department of Neurology, Laboratory of Neuroimmunology, Stanford University School of Medicine, Palo Alto, CA, United States
  38. 38. Lyon Neurosciences Research Center, Lyon I University, Lyon, France
  39. 39. Neuro-Ophthalmology Unit, Hospices Civils de Lyon, Lyon, France
  40. 40. Department of Multiple Sclerosis Therapeutics, Fukushima Medical University School of Medicine, Koriyama, Japan
  41. 41. Department of Ophthalmology, University of Alberta, AB, Canada
  42. 42. Department of Neurology, Razi University Hospital, University of Tunis El Manar, Tunis, Tunisia
  43. 43. Department of Neurology, Hospital Santo Tomas, Panama City, Panama
  44. 44. Instituto Conmemorativo Gorgas de Estudios de la Salud, Universidad Interamericana de Panama, Panama City, Panama
  45. 45. Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece
  46. 46. Servicio de Oftalmologia, Facultad de Medicina, Clinica Alemana Universidad del Desarrollo, Santiago, Chile
  47. 47. Department of Neurology, University of Zagreb School of Medicine, Zagreb, Croatia
  48. 48. Department of Neurology, University Hospital Center Zagreb, Zagreb, Croatia
  49. 49. Eye Hospital, University Medical Centre, Ljubljana, Slovenia
  50. 50. Department of Neurology, Hospital Clinic of Barcelona, Barcelona, Spain
  51. 51. Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
  52. 52. Aga Khan University Hospital, Nairobi, Kenya
  53. 53. Department of Neurology, Penang General Hospital, Penang, Malaysia
  54. 54. Department of Neurology, Kilimanjaro Christian Medical Center (KCMC), Moshi, Tanzania
  55. 55. Department of Neurology, Linkoping University Hospital, Linkoping, Sweden
  56. 56. Department of Neurology, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
  57. 57. Department of Neurology, Odense University Hospital, Odense, Denmark
  58. 58. Clinic of Neurology and Psychiatry for Children and Youth, Faculty of Medicine University of Belgrade, Belgrade, Serbia
  59. 59. Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  60. 60. Neuro-Ophthalmology Unit at Rabin Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
  61. 61. Multiple Sclerosis Center, Sheba Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
  62. 62. Department of Neurology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
  63. 63. Department of Neurology, National Cancer Center, Goyang, South Korea
  64. 64. Eye Center, Medical Center, Medical Faculty, University of Freiburg, Germany
  65. 65. Vita-Salute San Raffaele University, Experimental Neurophysiology Unit, Institute of Experimental Neurology-INSPE, Scientific Institute San Raffaele, Milan, Italy
  66. 66. Department of Neurology, Hadassah Medical Center and Faculty of Medicine, Hebrew University, Jerusalem, Israel
  67. 67. Department of Paediatrics and Inherited Metabolic Disorders, Department of Ophthalmology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
  68. 68. Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
  69. 69. Department of Neurology, Gabriel Toure University Hospital, Bamako, Mali
  70. 70. Service de Neurologie, Sclerose en Plaques, Pathologies de la Myeline et NeuroInflammation, Centre de Reference des Maladies Inflammatoires Rares du Cerveau et de la Moelle, Hopital Neurologique Pierre Wertheimer, Bron, France
  71. 71. School of Medicine, University College Dublin, Dublin, Ireland
  72. 72. Department of Neurology, St Vincent's University Hospital, Dublin, Ireland
  73. 73. Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal
  74. 74. Department of Ophthalmology, University Hospital of Martinique, Martinique, French West Indies, France
  75. 75. Division of Ophthalmology, University of Sao Paulo Medical School, Sao Paulo, Brazil
  76. 76. Department of Neurology, University of KwaZulu-Natal, Durban, South Africa
  77. 77. Department of Neuro-Ophthalmology, Instituto Paulista Da Visao, Higienopolis, Brazil
  78. 78. Department of Ophthalmology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain
  79. 79. Department of Neurology, Prime Healthcare Group, Dubai, United Arab Emirates
  80. 80. Department of Neurology, Tohoku Medical and Pharmaceutical University, Sendai, Japan
  81. 81. Department of Ophthalmology, Hospital Universitario La Paz, Madrid, Spain
  82. 82. Department of Neurology, School of Medicine UDELAR, Montevideo, Uruguay
  83. 83. Department of Ophthalmology, College of Medicine, University of Ibadan, Ibadan, Nigeria
  84. 84. Department of Ophthalmology, University of Benin, Benin City, Nigeria
  85. 85. Center for Advanced Neurological Research, Nitte University, Karnataka, India
  86. 86. Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charite- Universiatsmedizin Berlin, Berlin, Germany
  87. 87. Department of Ophthalmology of Ramon y Cajal Hospital, Alcala University Madrid, Madrid, Spain
  88. 88. Sydney Neurology, Sydney, NSW, Australia
  89. 89. Department of Neurology, Medical University of Lublin, Lublin, Poland
  90. 90. Department of General and Pediatric Ophthalmology Medical University of Lublin, Lublin, Poland
  91. 91. Grupo de Investigacion Biomedicina, Faculty of Medicine, Fundacion Universitaria Autonoma de las Americas, Risaralda, Colombia
  92. 92. Department of Ophthalmology, University Hospital of Bordeaux, Bordeaux, France
  93. 93. Department of Neurology, Centro Hospitalar Universitario Sao Joao and Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal
  94. 94. Department of Ophthalmology, Hospital Clinic of Barcelona, Barcelona, Spain
  95. 95. Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, United States
  96. 96. Department of Ophthalmology and Visual Science, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
  97. 97. Department of Neurology, Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Istanbul, Turkey
  98. 98. Department of Ophthalmology, University of Mississippi Medical Center, Jackson, MS, United States
  99. 99. Department of General Planning, Ho Chi Minh City Eye Hospital, Ho Chi Minh City, Viet Nam
  100. 100. Department of Neurology, National Paediatric Hospital Dr Juan P Garrahan, Buenos Aires, Argentina
  101. 101. Department of Ophthalmology, Faculty of Medicine, Ho Chi Minh City University of Medicine and Pharmacy, Hai Yen Vision Institute, Ho Chi Minh City, Viet Nam
  102. 102. Department of Neurology and Reflexology, The Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine
  103. 103. Department of Neurology, Cliniques Universitaires Saint-Luc Brussels, Belgium
  104. 104. Neurochemistry Unit, Institute of Neuroscience, UCLouvain, Brussels, Belgium
  105. 105. Department of Ophthalmology, Taipei Veterans General Hospital, National Yang-Ming Chiao-Tung University School of Medicine, Taipei, Taiwan
  106. 106. Department of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Germany
  107. 107. Department of Neurology, Auckland City Hospital, Auckland, New Zealand
  108. 108. Department of Neurology, Ain Shams University Hospitals, Cairo, Egypt
  109. 109. Department of Ophthalmology, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina
  110. 110. Department of Neurology, Department of Population Health, Department of Ophthalmology, New York University Grossman School of Medicine, New York, NY, United States
  111. 111. Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Faculty of Brain Sciences, London, United Kingdom
  112. 112. Unite de Neurologie Inflammatoire B4, CHU Pierre-Paul Riquet/Purpan, Toulouse, France

Source: The Lancet Neurology Published:2022


Abstract

There is no consensus regarding the classification of optic neuritis, and precise diagnostic criteria are not available. This reality means that the diagnosis of disorders that have optic neuritis as the first manifestation can be challenging. Accurate diagnosis of optic neuritis at presentation can facilitate the timely treatment of individuals with multiple sclerosis, neuromyelitis optica spectrum disorder, or myelin oligodendrocyte glycoprotein antibody-associated disease. Epidemiological data show that, cumulatively, optic neuritis is most frequently caused by many conditions other than multiple sclerosis. Worldwide, the cause and management of optic neuritis varies with geographical location, treatment availability, and ethnic background. We have developed diagnostic criteria for optic neuritis and a classification of optic neuritis subgroups. Our diagnostic criteria are based on clinical features that permit a diagnosis of possible optic neuritis; further paraclinical tests, utilising brain, orbital, and retinal imaging, together with antibody and other protein biomarker data, can lead to a diagnosis of definite optic neuritis. Paraclinical tests can also be applied retrospectively on stored samples and historical brain or retinal scans, which will be useful for future validation studies. Our criteria have the potential to reduce the risk of misdiagnosis, provide information on optic neuritis disease course that can guide future treatment trial design, and enable physicians to judge the likelihood of a need for long-term pharmacological management, which might differ according to optic neuritis subgroups. © 2022 Elsevier Ltd
Experts (# of related papers)
Other Related Docs
11. Mri Signs of Cns Demyelinating Diseases, Multiple Sclerosis and Related Disorders (2021)
24. Color Blindness Among Multiple Sclerosis Patients in Isfahan, Journal of Research in Medical Sciences (2012)
25. Whole Spinal Transverse Myelitis in Neuromyelitis Optica Spectrum Disorder, Multiple Sclerosis and Related Disorders (2024)
49. Orbital Doppler Evaluation of Blood Flow Velocities in Optic Neuritis., Korean journal of ophthalmology : KJO (2012)