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Diagnosis and Classification of Optic Neuritis Publisher Pubmed

Summary: Unlocking the mysteries of optic neuritis: New criteria may revolutionize diagnosis and improve treatment, especially in diseases like multiple sclerosis. #OpticNeuritis #MedicalResearch

Petzold A1, 2, 3 ; Fraser CL4 ; Abegg M5 ; Alroughani R6 ; Alshowaeir D7 ; Alvarenga R8 ; Andris C9 ; Asgari N10 ; Barnett Y11 ; Battistella R12 ; Behbehani R13 ; Berger T14 ; Bikbov MM15 ; Biotti D112 Show All Authors
Authors
  1. Petzold A1, 2, 3
  2. Fraser CL4
  3. Abegg M5
  4. Alroughani R6
  5. Alshowaeir D7
  6. Alvarenga R8
  7. Andris C9
  8. Asgari N10
  9. Barnett Y11
  10. Battistella R12
  11. Behbehani R13
  12. Berger T14
  13. Bikbov MM15
  14. Biotti D112
  15. Biousse V16
  16. Boschi A17, 18
  17. Brazdil M19, 20
  18. Brezhnev A21
  19. Calabresi PA22
  20. Cordonnier M23
  21. Costello F24
  22. Cruz FM25
  23. Cunha LP26
  24. Daoudi S27
  25. Deschamps R28
  26. De Seze J29
  27. Diem R30
  28. Etemadifar M31
  29. Floresrivera J32
  30. Fonseca P33, 34
  31. Frederiksen J35, 36
  32. Frohman E37
  33. Frohman T37
  34. Tilikete CF38, 39
  35. Fujihara K40
  36. Galvez A41
  37. Gouider R42
  38. Gracia F43, 44
  39. Grigoriadis N45
  40. Guajardo JM46
  41. Habek M47, 48
  42. Hawlina M49
  43. Martinezlapiscina EH50, 51
  44. Hooker J52
  45. Hor JY53
  46. Howlett W54
  47. Huanglink Y55
  48. Idrissova Z56
  49. Illes Z57
  50. Jancic J58
  51. Jindahra P59
  52. Karussis D61
  53. Kerty E62
  54. Kim HJ63
  55. Lagreze W64
  56. Leocani L65
  57. Levin N66
  58. Liskova P67
  59. Liu Y68
  60. Maiga Y69
  61. Marignier R70
  62. Mcguigan C71, 72
  63. Meira D73
  64. Merle H74
  65. Monteiro MLR75
  66. Moodley A76
  67. Moura F77
  68. Munoz S78
  69. Mustafa S79
  70. Nakashima I80
  71. Noval S81
  72. Oehninger C82
  73. Ogun O83
  74. Omoti A84
  75. Pandit L85
  76. Paul F86
  77. Rebolleda G87
  78. Reddel S88
  79. Rejdak K89
  80. Rejdak R90
  81. Rodriguezmorales AJ91
  82. Rougier MB92
  83. Sa MJ93
  84. Sanchezdalmau B94
  85. Saylor D95
  86. Shatriah I96
  87. Siva A97
  88. Stiebelkalish H60
  89. Szatmary G98
  90. Ta L99
  91. Tenembaum S100
  92. Tran H101
  93. Trufanov Y102
  94. Van Pesch V103, 104
  95. Wang AG105
  96. Wattjes MP106
  97. Willoughby E107
  98. Zakaria M108
  99. Zvornicanin J109
  100. Balcer L110
  101. Plant GT111

Source: The Lancet Neurology Published:2022


Abstract

There is no consensus regarding the classification of optic neuritis, and precise diagnostic criteria are not available. This reality means that the diagnosis of disorders that have optic neuritis as the first manifestation can be challenging. Accurate diagnosis of optic neuritis at presentation can facilitate the timely treatment of individuals with multiple sclerosis, neuromyelitis optica spectrum disorder, or myelin oligodendrocyte glycoprotein antibody-associated disease. Epidemiological data show that, cumulatively, optic neuritis is most frequently caused by many conditions other than multiple sclerosis. Worldwide, the cause and management of optic neuritis varies with geographical location, treatment availability, and ethnic background. We have developed diagnostic criteria for optic neuritis and a classification of optic neuritis subgroups. Our diagnostic criteria are based on clinical features that permit a diagnosis of possible optic neuritis; further paraclinical tests, utilising brain, orbital, and retinal imaging, together with antibody and other protein biomarker data, can lead to a diagnosis of definite optic neuritis. Paraclinical tests can also be applied retrospectively on stored samples and historical brain or retinal scans, which will be useful for future validation studies. Our criteria have the potential to reduce the risk of misdiagnosis, provide information on optic neuritis disease course that can guide future treatment trial design, and enable physicians to judge the likelihood of a need for long-term pharmacological management, which might differ according to optic neuritis subgroups. © 2022 Elsevier Ltd
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