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The Landscape of Exosomal Non-Coding Rnas in Breast Cancer Drug Resistance, Focusing on Underlying Molecular Mechanisms Publisher



Rezaee M1, 2 ; Mohammadi F3 ; Keshavarzmotamed A4 ; Yahyazadeh S5 ; Vakili O6, 7 ; Milasi YE7 ; Veisi V8 ; Dehmordi RM7, 9 ; Asadi S10 ; Ghorbanhosseini SS7 ; Rostami M11 ; Alimohammadi M12 ; Azadi A13 ; Moussavi N14 Show All Authors
Authors
  1. Rezaee M1, 2
  2. Mohammadi F3
  3. Keshavarzmotamed A4
  4. Yahyazadeh S5
  5. Vakili O6, 7
  6. Milasi YE7
  7. Veisi V8
  8. Dehmordi RM7, 9
  9. Asadi S10
  10. Ghorbanhosseini SS7
  11. Rostami M11
  12. Alimohammadi M12
  13. Azadi A13
  14. Moussavi N14
  15. Asemi Z15
  16. Aminianfar A15
  17. Mirzaei H15
  18. Mafi A7, 16

Source: Frontiers in Pharmacology Published:2023


Abstract

Breast cancer (BC) is the most common malignancy among women worldwide. Like many other cancers, BC therapy is challenging and sometimes frustrating. In spite of the various therapeutic modalities applied to treat the cancer, drug resistance, also known as, chemoresistance, is very common in almost all BCs. Undesirably, a breast tumor might be resistant to different curative approaches (e.g., chemo- and immunotherapy) at the same period of time. Exosomes, as double membrane-bound extracellular vesicles 1) secreted from different cell species, can considerably transfer cell products and components through the bloodstream. In this context, non-coding RNAs (ncRNAs), including miRNAs, long ncRNAs (lncRNAs), and circular RNAs (circRNAs), are a chief group of exosomal constituents with amazing abilities to regulate the underlying pathogenic mechanisms of BC, such as cell proliferation, angiogenesis, invasion, metastasis, migration, and particularly drug resistance. Thereby, exosomal ncRNAs can be considered potential mediators of BC progression and drug resistance. Moreover, as the corresponding exosomal ncRNAs circulate in the bloodstream and are found in different body fluids, they can serve as foremost prognostic/diagnostic biomarkers. The current study aims to comprehensively review the most recent findings on BC-related molecular mechanisms and signaling pathways affected by exosomal miRNAs, lncRNAs, and circRNAs, with a focus on drug resistance. Also, the potential of the same exosomal ncRNAs in the diagnosis and prognosis of BC will be discussed in detail. Copyright © 2023 Rezaee, Mohammadi, Keshavarzmotamed, Yahyazadeh, Vakili, Milasi, Veisi, Dehmordi, Asadi, Ghorbanhosseini, Rostami, Alimohammadi, Azadi, Moussavi, Asemi, Aminianfar, Mirzaei and Mafi.
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