Effects of Co-Supplementation With Alpha-Linolenic Acid and L-Carnitine on Inflammatory Status and Oxidative Stress in Women With Migraine: A Randomized, Triple-Blind, Placebo-Controlled Trial Publisher

Summary: Study finds ALA and L-carnitine combo reduces inflammation in women with migraines, easing symptoms. #MigraineRelief #Supplements

Golpourhamedani S¹ ; Bagherniya M¹ ; Khorvash F² ; Feizi A³ ; Sharma M^{4, 5} ; Askari G¹
Source: Journal of Functional Foods Published:2024

Abstract

Migraine is associated with inflammation and oxidative imbalance. This randomized controlled trial examined the effects of alpha-linolenic acid (ALA) and L-carnitine co-supplementation on inflammatory status and oxidative stress in 80 women with migraine. Serum markers were measured before and after the intervention. Compared to placebo, ALA and L-carnitine co-supplementation significantly reduced nitric oxide (−6.10; 95 % CI (−9.08, −3.12) vs. 1.77; 95 % CI (−3.21, 6.76) nmol/mL, P = 0.038), malondialdehyde (−5.47; 95 % CI (−6.33, −4.62) vs. −0.15; 95 % CI (−0.50, −0.20) nmol/mL, P = 0.011), and C-reactive protein (−0.44; 95 % CI (−0.47, −0.41) vs. −0.02; 95 % CI (−0.05, 0.007) mg/L, P = 0.007) levels. It also increased total antioxidant capacity (185.60; 95 % CI (159.69, 211.50) vs. 5.22; 95 % CI (−29.21, 39.66) nmol/mL, P = 0.045) and superoxide dismutase activity (301.42; 95 % CI (230.63, 372.21) vs. 15.20; 95 % CI (−8.15, 38.55) U/mL, P = 0.009), suggesting potential benefits for migraine management. © 2024