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The Effects of Inulin Supplementation on Clinical Indices, Oxidative Stress and Inflammatory Biomarkers in Women With Migraine: A Double-Blind, Placebo-Controlled, Randomized Trial Publisher



Vajdi M1 ; Khorvash F2 ; Askari G1
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Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Iran
  2. 2. Neurology Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Functional Foods Published:2024


Abstract

The present study aimed to investigate the effects of 12 weeks inulin supplementation (10 g/d) on clinical indices and biomarkers of inflammation, gut permeability, and oxidative stress in eighty women with migraine. Before and after the trial, we assessed the migraine index (MI), migraine headache index score (MHIS), headache diary results (HDR), high-sensitivity C-reactive protein (hs-CRP), zonulin, nitric oxide (NO), and oxidative stress factors. Inulin supplementation improved total antioxidant capacity (284.07 vs. 26.92, P=0.046), and reduced hs-CRP (−0.69 vs. 0.14), NO (−5.65 vs. 2.57) and oxidative stress index levels (−0.21 vs. 0.05) compared to placebo. Moreover, inulin supplementation resulted in a significant decrease in the score of MHIS, MI, and HDR (all P-values < 0.05). However, no significant change was observed in total oxidative status, and zonulin levels. This study showed that inulin supplementation can favorably improve clinical symptoms, inflammatory and oxidative stress biomarkers in women with migraine. © 2024 The Author(s)
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