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The Effects of Synbiotic Supplementation on Oxidative Stress and Clinical Symptoms in Women With Migraine: A Double‐Blind, Placebo‐Controlled, Randomized Trial Publisher



Ghavami A1 ; Khorvash F2 ; Khalesi S3 ; Heidari Z4 ; Askari G1
Authors
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Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Neurology Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Physical Activity Research Group, Appleton Institute and School of Health Medical and Applied Sciences, Central Queensland University, Brisbane, Australia
  4. 4. Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Functional Foods Published:2021


Abstract

Oxidative stress may play an important role in migraine pathogenesis. This randomized controlled trial aimed to investigate the effect of 12 weeks synbiotic supplementation on the oxidative stress and clinical symptoms of migraine in eighty women. The effect of the intervention on the total antioxidant capacity (TAC), nitric oxide (NO), oxidative stress index (OSI), total oxidant status (TOS), migraine index (MI), headache diary result (HDR) and migraine headache index score (MHIS) were investigated using bivariate comparison. Synbiotic supplementation improved TAC (381.77 vs 43.17 nmol/ml, P = 0.034), and reduced NO (-4.62 vs 0.55 nmol/ml, P = 0.021), OSI levels (-0.33 vs 0.0009, P = 0.027), and MI (-8.27 vs −3.20, P = 0.013) compared to placebo. A positive correlation between the severity of migraine headache and NO level was observed following synbiotic supplementation (r = 0.44, P = 0.002). Synbiotics may reduce oxidative stress and improve migraine symptoms in women and help as a supplemental therapy in managing migraine headaches. © 2021
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