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The Radioprotective Effect of Resveratrol Against Genotoxicity Induced by Γ-Irradiation in Mice Blood Lymphocytes Publisher

Summary: Research in mice suggests resveratrol (from grapes) can protect blood cells from radiation damage, likely by fighting free radicals. #RadiationProtection #NutritionScience

Koohian F1 ; Shanei A1 ; Shahbazigahrouei D1 ; Hejazi SH2 ; Moradi MT3
Authors

Source: Dose-Response Published:2017


Abstract

In this study, we evaluated whether the protective potential of resveratrol (RSV; 3,5,4'-trihydroxy-trans-stilbene) against γ-radiation caused damages in peripheral blood lymphocyte of mice. Resveratrol as a polyphenolic compound scavenges free radicals. Various doses of RSV were administered intraperitoneally 2 hours to adult male mice before a single dose of whole-body γ-irradiation (2 Gy). To assess the protective ability of RSV, the alkaline comet assay in blood lymphocyte of mice was performed and the total comet score was evaluated. The results of the alkaline comet assay showed that RSV significantly inhibited radiationinduced DNA damage. We observed that RSV protects blood lymphocyte against radiation-induced damage in mice. © The Author(s) 2017.
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