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Effect of Bariatric Surgery on the Circulating Level of Adiponectin, Chemerin, Plasminogen Activator Inhibitor-1, Leptin, Resistin, and Visfatin: A Systematic Review and Meta-Analysis Publisher Pubmed



Askarpour M1 ; Alizadeh S2 ; Hadi A3, 4 ; Symonds ME5 ; Miraghajani M6 ; Sheikhi A1 ; Ghaedi E2, 7
Authors
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Authors Affiliations
  1. 1. Department of Community Nutrition, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Cellular and Molecular Nutrition, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Halal Research Center of IRI, FDA, Tehran, Iran
  4. 4. Department of Clinical Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Early Life Research Unit, Division of Child Health, Obstetrics and Gynaecology, University of Nottingham, Nottingham, United Kingdom
  6. 6. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran

Source: Hormone and Metabolic Research Published:2020


Abstract

Different adipokines secreted from adipose tissue, exert a range of physiological effects. The aim of present systematic review and meta-analysis was to critically investigate the consequence of bariatric surgery on circulating adipokines, that is, adiponectin, leptin, visfatin, resistin, plasminogen activator inhibitor, and chemerin. After systematically checking the following electronic databases: ISI web of Science, Scopus and PubMed without limitation in time and language up to February 2019, a pool based on a random effect model was established. Eighty-five eligible studies were entered for quantitative analysis. Our meta-analysis revealed that circulating adiponectin increased significantly after bariatric surgery [Standardized mean difference (SMD)=1.401, 95% CI: 1.101, 1.701, p<0.001]; whilst leptin (SMD=-2.178, 95% CI: -2.433, -1.923, p<0.001), PAI-1 (-14.928 ng/ml 95% CI: -21.794, -8.063, p<0.001), and chemerin (-50.238 ng/ml 95% CI: -85.708, -14.768, p<0.001) decreased. However, serum visfatin (2.05 ng/ml, 95% CI: -5.07, 9.17, p=0.573) and resistin (-2.080 ng/ml, 95% CI: -5.352, 1.192, p=0.21) were unchanged. In conclusion, bariatric surgery is associated with a reduction in specific adipokines including leptin, chemerin, and PAI-1, whereas adiponectin is raised, adaptations that could be indicative of improved fat mass and function. © 2020 EDP Sciences. All rights reserved.
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