Impact of Vitamin D on Insulin Resistance in Patients With Type Ii Diabetes: A Comprehensive Cohort Design



Vahedian M¹ ; Maracy MR¹ ; Parham M² Show Affiliations
Source: Journal of Isfahan Medical School Published:2013

Abstract

Background: Some observational studies show that the consumption of vitamin D is one of the preventive methods which may potentially be useful in the reduction of diabetes type ΙΙ development, insulin resistance, impaired glucose tolerance, and metabolic syndrome. The purpose of this study was to evaluate the effect of vitamin D on insulin resistance in patients with type II diabetes. Methods: This study was conducted as a comprehensive cohort design in Qom, Iran, in 2012. The participants were 120 patients with type II diabetes of whom, 58 agreed to be randomized into two groups and 62 patients were allocated to their preferences. For randomized treatment group, a pill of vitamin D which contained 50000 units was used weekly and orally for duration of 3 months. In the control group, the placebo pill of vitamin D was prescribed by the same method. In the preferential group, patients received neither vitamin D nor placebo. The value of insulin resistance was defined as a score greater than 3.87 in HOMA-IR (Homeostatic model assessment -estimated insulin resistance) index. Findings: Vitamin D could significantly decrease the HOMA-IR index in the randomized group after controlling for the variables of sex, age, body mass index (BMI), waist, duration of diabetes, heart disease, and HOMA-IR index at the beginning of the study. The reduction was not statistically significant in the preferential group. Conclusion: Vitamin D can affect the reduction of fasting blood sugar (FBS) and insulin resistance in the randomized group but in the preferential group it cannot.