Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Relapse Rate of Inflammatory Bowel Disease (Ibd) in Patients Who Discontinue Anti-Tnf Therapy: A Systematic Review and Meta-Analysis



Ebrahimi F1 ; Torkian S2 ; Zarefarashbandi E3 ; Tamizifar B4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Epidemiology & Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Epidemiology, School of Health, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Clinical Informationist Research Group, Health Information Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Isfahan Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Iranian Journal of Public Health Published:2024

Abstract

Background: Inflammatory bowel disease (IBD) patients who cease anti-tumor necrosis factor (TNF) therapy are at risk of relapse, which is a matter of concern for the medical community. This study aimed to determine the relapse rate of IBD in patients who cease anti-TNF therapy. Methods: A systematic search of international databases (Medline, Web of Sciences, Scopus, and EMBASE) was conducted until Mar 9th, 2022. The random effects model was used to calculate the IBD relapse rate, accompanied by a 95% confidence interval. Results: The IBD relapse rate in patients who discontinued anti-TNF therapy was 44%. The pooled IBD-UC and IBD-CD relapse rate in patients who stopped anti-TNF therapy were 43% and 46%, respectively. The studies using infliximab (IFX) showed a pooled IBD relapse rate of 45%, and the IBD relapse rate in the IFX/ADA (Adalimumab) group was 42%. The IBD relapse rate for papers with treatment durations of less than or equal to 12 months was 51%, while for articles with treatment durations of more than 12 months, it was 30%. Conclusion: This study emphasizes the need for careful evaluation and monitoring of IBD patients who cease anti-TNF therapy, as well as further investigation of alternative treatments for those who exhibit intolerance or inadequate response to anti-TNF therapy. © 2024 Ebrahimi et al.
Related Docs
View other Related Docs
1. All-Cause Mortality of Hospitalized Inflammatory Bowel Disease Patients: A Multicenter Study From Iran, Gastroenterology and Hepatology from Bed to Bench (2024)
2. Promising Effect of Infliximab on the Extent of Involvement in Ulcerative Colitis, Journal of Research in Medical Sciences (2011)
3. A Systematic Review and Meta-Analysis of Prospective Studies on Obesity and Risk of Inflammatory Bowel Disease, Nutrition Reviews (2022)
4. Survival and Recurrence Time Among Patients With Colon Cancer Reffered to Alzahra Hospital, Isfahan, Iran, During 2001-2010, Journal of Isfahan Medical School (2017)
5. Efficacy and Safety of Ibrutinib in Mantle Cell Lymphoma: A Systematic Review and Meta-Analysis, DARU, Journal of Pharmaceutical Sciences (2022)
6. The Association of Ultra-Processed Food Consumption With Adult Inflammatory Bowel Disease Risk: A Systematic Review and Dose-Response Meta-Analysis of 4 035 694 Participants, Nutrition Reviews (2024)
7. Association of Adult Height With Cardiovascular Mortality: A Systematic Review and Meta-Analysis of Cohort Studies, International Journal of Clinical Practice (2022)
8. Association Between Inflammatory Potential of the Diet and Ulcerative Colitis: A Case-Control Study, Frontiers in Nutrition (2021)
Experts (# of related papers)
View all Related Experts
Peyman Adibi (11)
Babak Tamizifar (4)
Other Related Docs
9. Iranian Association of Gastroenterology and Hepatology Position Statement in Management of Inflammatory Bowel Disease by Using Biological Drugs: Expert View; [بیانیه انجمن گوارش و کبد ایران در مورد مصرف داروهای بیولوژیک در بیماری هایالتهابی روده], Govaresh (2022)
10. Clinical Phenotype and Disease Course of Inflammatory Bowel Disease in Iran: Results of the Iranian Registry of Crohn's and Colitis (Ircc), Archives of Iranian Medicine (2024)
11. Effects of Venlafaxine on Gastrointestinal Symptoms, Depression, Anxiety, Stress, and Quality of Life in Patients With the Moderate-To-Severe Irritable Bowel Syndrome, Journal of Research in Medical Sciences (2020)
12. A Systematic Review and Meta-Analysis of Prevalence and Clinical Features of Upper Gastrointestinal (Ugi) Tract Crohn's Disease in Adults Compared to Non-Ugi Types, JGH Open (2023)
13. Inflammatory Bowel Disease Registry and Monitoring: Feasibility Study and Application (Isfahan Inflammatory Bowel Disease Surveillance Project), International Journal of Preventive Medicine (2019)
14. Causes of Colectomy in Patients With Ulcerative Colitis: Findings From an Iranian National Registry, Archives of Iranian Medicine (2024)
15. Comparison of Pelvic Floor Dysfunction in Women With Ulcerative Colitis and Healthy Population, Middle East Journal of Digestive Diseases (2024)
16. Effects of Spirulina Supplementation in Patients With Ulcerative Colitis: A Double-Blind, Placebo-Controlled Randomized Trial, BMC Complementary Medicine and Therapies (2024)
17. Efficacy and Safety of Proposed Bevacizumab Biosimilar Be1040v in Patients With Metastatic Colorectal Cancer: A Phase Iii, Randomized, Double-Blind, Noninferiority Clinical Trial, Clinical Therapeutics (2020)
18. Effects of Vitamin D Supplementation on Serum 25‑Hydroxy Cholecalciferol in Inflammatory Bowel Diseases: A Meta‑Analysis of Randomized Clinical Trials, International Journal of Preventive Medicine (2024)
19. Melatonin Supplementation in Preclinical Colitis Models: A Systematic Review and Dose-Response Meta-Analysis on Inflammation, Oxidative Stress, and Colon Repair, PharmaNutrition (2024)
20. Association of Ultra-Processed Food Intake With Risk of Inflammatory Bowel Disease: Prospective Cohort Study, The BMJ (2021)
21. Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-Analyses of Randomized Clinical Trials, Nutrition Reviews (2025)
22. Relationship Between Articular and Nonarticular Manifestations in Inflammatory Bowel Diseases, Journal of Research in Medical Sciences (2016)
23. The Prevalence of Adherent-Invasive Escherichia Coli and Its Association With Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis, Frontiers in Medicine (2021)
24. Inflammatory Cytokines and Oxidative Stress Biomarkers in Irritable Bowel Syndrome: Association With Digestive Symptoms and Quality of Life, Cytokine (2017)
25. Emerging Epidemic of Inflammatory Bowel Disease in a Middle Income Country: A Nation-Wide Study From Iran, Archives of Iranian Medicine (2016)
26. The Effect of Biofeedback Therapy on Dyssynergic Constipation in Patients With or Without Irritable Bowel Syndrome, Journal of Research in Medical Sciences (2014)
27. Medication Adherence With Polypill in Cardiovascular Disease and High-Risk Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Involving 7364 Participants, Current Problems in Cardiology (2024)
28. Comparison the Effects and Side Effects of Covid-19 Vaccination in Patients With Inflammatory Bowel Disease (Ibd): A Systematic Scoping Review, BMC Gastroenterology (2022)
29. The Effect of Pro-/Synbiotic Supplementation on the Brain-Derived Neurotrophic Factor: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Food and Function (2022)
30. Iranian Registry of Crohn’S and Colitis: Study Profile of First Nation-Wide Inflammatory Bowel Disease Registry in Middle East, Intestinal Research (2019)
31. Screening Tools for Obstructive Sleep Apnea in Pregnant Women: An Extended and Updated Systematic Review and Meta‑Analysis, International Journal of Preventive Medicine (2024)
32. The Effects of Phytochemicals on Serum Triglycerides in Subjects With Hypertriglyceridemia: A Systematic Review of Randomized Controlled Trials, Phytotherapy Research (2023)
33. Effect of Sesame (Sesamum Indicum L.) Consumption on Glycemic Control in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2023)
34. Anti-Inflammatory Effects of Heparin and Its Derivatives: A Systematic Review, Advances in Pharmacological Sciences (2015)
35. Associations of Antibiotics, Hormonal Therapies, Oral Contraceptives, and Long-Term Nsaids With Inflammatory Bowel Disease: Results From the Prospective Urban Rural Epidemiology (Pure) Study, Clinical Gastroenterology and Hepatology (2023)