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Relationship Between Articular and Nonarticular Manifestations in Inflammatory Bowel Diseases Publisher



Fatemi A1 ; Hashemi Jazi H2 ; Emami MH3 ; Kazemizadeh A4 ; Tavakkoli H5 ; Smiley A6
Authors
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Authors Affiliations
  1. 1. Departments of Rheumatology, Isfahan University of Medical Sciences, Najafabad, Isfahan, Iran
  2. 2. Departments of Internal Medicine, Isfahan University of Medical Sciences, Najafabad, Isfahan, Iran
  3. 3. Departments of Gastroenterology, Poursina Hakim Research Institute, Isfahan University of Medical Sciences, Najafabad, Isfahan, Iran
  4. 4. Departments of Gastroenterology, Poursina Hakim Research Institute, Islamic Azad University of Najafabad, Najafabad, Isfahan, Iran
  5. 5. Departments of Gastroenterology, Isfahan University of Medical Sciences, Najafabad, Isfahan, Iran
  6. 6. Department of Epidemiology, Indiana University School of Public Health, Bloomington, IN, United States

Source: Journal of Research in Medical Sciences Published:2016


Abstract

Background: Musculoskeletal manifestations (MSM) of inflammatory bowel diseases (IBDs) are usually the most frequent extraintestinal manifestations. However, they are not paid enough attention during regular office visits. This cross-sectional study aimed to draw a clinical picture of MSM and their relationships with other findings in patients with IBD. Materials and Methods: Patients of our IBD cohort between March 2012 and September 2013 were consecutively evaluated. Those with current or past history of any MSM were examined by a rheumatologist. The outcome of interest was different MSMs. Distribution of IBD manifestations between the two groups of patients with (n = 20) and without (n = 253) MSM was compared. Logistic regression analysis was employed to find the relationships of demographic, clinical, and laboratory findings with MSM. Results: Two hundred and seventy-three patients were enrolled. Forty-two patients (15.4%) had extraintestinal manifestations of which twenty patients (7.5%) had at least one MSM. 7/20 patients (35%) versus 22/253 (8.7%) had other extraintestinal manifestations (P = 0.0001). 12/20 patients (57%) had arthritis (polyarthritis, 33% and oligoarthritis, 67%). The most frequent involved joints were knee and ankle observed in 8 (40%) and 7 (35%) patients, respectively. The inflammatory back pain was recorded in 5/20 patients (25%) whereas two patients (10%) had ankylosing spondylitis. In regression analysis, oral aphthous (odds ratio [OR] =8.8 [95% confidence intervals (CI), 1.7–45], P = 0.009) and other extraintestinal manifestations (OR = 5.2 [95% CI, 1.3–20], P = 0.02) were significantly related with arthritis. Conclusion: The most frequent extraintestinal manifestations in patients with IBD were MSM. Knee and ankle were the most frequent involved joints. Extraintestinal manifestations were determinant variables of arthritis. © 2016 Journal of Research in Medical Sciences.
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