Ethnicity Based Differences in Statin Use and Hypercholesterolemia Control Among Patients With Premature Coronary Artery Disease-Results of I-Pad Study

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Ethnicity Based Differences in Statin Use and Hypercholesterolemia Control Among Patients With Premature Coronary Artery Disease-Results of I-Pad Study Publisher

Summary: Statin use for LDL control varies by gender & ethnicity in premature CAD patients; Arabs show better control. #Statins #CAD

Karimi R^{1, 8} ; Zarepur E^{2, 3} ; Khosravi A^{4, 5} ; Mohammadifard N² ; Nouhi F^{5, 6} ; Alikhasi H⁷ ; Nasirian S⁸ ; Sadeghi M⁹ ; Roohafza H⁹ ; Moezi Bady SA^{10, 11} ; Solati K¹³ ; Lotfizadeh M¹⁴ ; Ghaffari S^{5, 15} ; Javanmardi E¹⁶ Show All Authors

Karimi R^{1, 8}
Zarepur E^{2, 3}
Khosravi A^{4, 5}
Mohammadifard N²
Nouhi F^{5, 6}
Alikhasi H⁷
Nasirian S⁸
Sadeghi M⁹
Roohafza H⁹
Moezi Bady SA^{10, 11}
Solati K¹³
Lotfizadeh M¹⁴
Ghaffari S^{5, 15}
Javanmardi E¹⁶
Gholipour M¹⁷
Cheraghi M¹⁸
Assareh A^{5, 19}
Haybar H¹⁹
Namayandeh SM²⁰
Kojuri J^{5, 22}
Mansourian M⁸
Sarrafzadegan N^{5, 8, 23}

Source: International Journal of Cardiology: Cardiovascular Risk and Prevention Published:2023

Abstract

Background: Statins use is the most important treatment for high LDL cholesterol in patients with premature coronary artery disease (CAD). Previous reports have shown racial and gender differences in statin use in the general population, but this wasn't studied in premature CAD based on different ethnicities. Methods and results: Our study includes 1917 men and women with confirmed diagnosis of premature CAD. Logistic regression model was used to evaluate the high LDL cholesterol control in the groups and the OR with 95% confidence interval (CI) was reported as the effect size. After adjustment for confounders, the odds of controlling LDL in women taking Lovastatin, Rosuvastatin, and Simvastatin were 0.27 (0.03, 0.45) lower in comparison with men. Also, in participant who took 3 types of statins, the odds of controlling LDL were significantly different between Lor and Arab compared with Fars ethnicity. After adjustment to all confounders (full model), the odds of controlling LDL were lower for Gilak in Lovastatin, Rosuvastatin, and Simvastatin by 0.64 (0.47, 0.75); 0.61 (0.43, 0.73); 0.63 (0.46, 0.74) respectively and higher for Arab in Lovastatin, Rosuvastatin, and Simvastatin by 4.63 (18.28, 0.73); 4.67 (17.47, 0.74); 4.55 (17.03, 0.71) respectively compared to Fars. Conclusions: Major differences in different gender and ethnicities may have had led to disparities in statin use and LDL control. Awareness of the statins impact on high LDL cholesterol based on different ethnicities can help health decision-makers to close the observed gaps in statin use and control LDL to prevent CAD problems. © 2023 The Authors

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Style	Citing Format
MLA	Karimi R, et al.. "Ethnicity Based Differences in Statin Use and Hypercholesterolemia Control Among Patients With Premature Coronary Artery Disease-Results of I-Pad Study." International Journal of Cardiology: Cardiovascular Risk and Prevention, vol. 16, no. , 2023, pp. -.
APA	Karimi R, Zarepur E, Khosravi A, Mohammadifard N, Nouhi F, Alikhasi H, Nasirian S, Sadeghi M, Roohafza H, Moezi Bady SA, Solati K, Lotfizadeh M, Ghaffari S, Javanmardi E, Gholipour M, Cheraghi M, Assareh A, Haybar H, Namayandeh SM, ... Sarrafzadegan N (2023). Ethnicity Based Differences in Statin Use and Hypercholesterolemia Control Among Patients With Premature Coronary Artery Disease-Results of I-Pad Study. International Journal of Cardiology: Cardiovascular Risk and Prevention, 16(), -.
Chicago	Karimi R, Zarepur E, Khosravi A, Mohammadifard N, Nouhi F, Alikhasi H, Nasirian S, et al.. "Ethnicity Based Differences in Statin Use and Hypercholesterolemia Control Among Patients With Premature Coronary Artery Disease-Results of I-Pad Study." International Journal of Cardiology: Cardiovascular Risk and Prevention 16, no. (2023): -.
Harvard	Karimi R et al. (2023) 'Ethnicity Based Differences in Statin Use and Hypercholesterolemia Control Among Patients With Premature Coronary Artery Disease-Results of I-Pad Study', International Journal of Cardiology: Cardiovascular Risk and Prevention, 16(), pp. -.
Vancouver	Karimi R, Zarepur E, Khosravi A, Mohammadifard N, Nouhi F, Alikhasi H, et al.. Ethnicity Based Differences in Statin Use and Hypercholesterolemia Control Among Patients With Premature Coronary Artery Disease-Results of I-Pad Study. International Journal of Cardiology: Cardiovascular Risk and Prevention. 2023;16():-.
BibTex	@article{ author = {Karimi R and Zarepur E and Khosravi A and Mohammadifard N and Nouhi F and Alikhasi H and Nasirian S and Sadeghi M and Roohafza H and Moezi Bady SA and Solati K and Lotfizadeh M and Ghaffari S and Javanmardi E and Gholipour M and Cheraghi M and Assareh A and Haybar H and Namayandeh SM and Kojuri J and Mansourian M and Sarrafzadegan N}, title = {Ethnicity Based Differences in Statin Use and Hypercholesterolemia Control Among Patients With Premature Coronary Artery Disease-Results of I-Pad Study}, journal = {International Journal of Cardiology: Cardiovascular Risk and Prevention}, volume = {16}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Karimi R AU - Zarepur E AU - Khosravi A AU - Mohammadifard N AU - Nouhi F AU - Alikhasi H AU - Nasirian S AU - Sadeghi M AU - Roohafza H AU - Moezi Bady SA AU - Solati K AU - Lotfizadeh M AU - Ghaffari S AU - Javanmardi E AU - Gholipour M AU - Cheraghi M AU - Assareh A AU - Haybar H AU - Namayandeh SM AU - Kojuri J AU - Mansourian M AU - Sarrafzadegan N TI - Ethnicity Based Differences in Statin Use and Hypercholesterolemia Control Among Patients With Premature Coronary Artery Disease-Results of I-Pad Study JO - International Journal of Cardiology: Cardiovascular Risk and Prevention VL - 16 IS - SP - EP - PY - 2023 ER -