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Ethnicity Based Differences in Statin Use and Hypercholesterolemia Control Among Patients With Premature Coronary Artery Disease-Results of I-Pad Study Publisher



Karimi R1, 8 ; Zarepur E2, 3 ; Khosravi A4, 5 ; Mohammadifard N2 ; Nouhi F5, 6 ; Alikhasi H7 ; Nasirian S8 ; Sadeghi M9 ; Roohafza H9 ; Moezi Bady SA10, 11 ; Solati K13 ; Lotfizadeh M14 ; Ghaffari S5, 15 ; Javanmardi E16 Show All Authors
Authors
  1. Karimi R1, 8
  2. Zarepur E2, 3
  3. Khosravi A4, 5
  4. Mohammadifard N2
  5. Nouhi F5, 6
  6. Alikhasi H7
  7. Nasirian S8
  8. Sadeghi M9
  9. Roohafza H9
  10. Moezi Bady SA10, 11
  11. Solati K13
  12. Lotfizadeh M14
  13. Ghaffari S5, 15
  14. Javanmardi E16
  15. Gholipour M17
  16. Cheraghi M18
  17. Assareh A5, 19
  18. Haybar H19
  19. Namayandeh SM20
  20. Kojuri J5, 22
  21. Mansourian M8
  22. Sarrafzadegan N5, 8, 23
Show Affiliations
Authors Affiliations
  1. 1. Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Interventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Cardiology, Medicine School, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. The Iranian Network of Cardiovascular Research (INCVR), Iran
  6. 6. Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  10. 10. Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
  11. 11. Clinical Research Development Unit, Imam Reza Hospital, Birjand University of Medical Sciences, Birjand, Iran
  12. 12. Cardiovascular Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  13. 13. Department of Psychiatry, Shahrekord University of Medical Sciences, Shahrekord, Iran
  14. 14. Social determinants of Health Research Center, Shahrekord University of Medical Sciences, Iran
  15. 15. Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  16. 16. Department of Cardiovascular Medicine, Heart Center, Maraghe University of Medical Sciences, Amiralmomenin Hospital, Iran
  17. 17. Department of Cardiology, Healthy Heart Research Center, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  18. 18. Department of Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Science, Khorramabad, Iran
  19. 19. Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  20. 20. Yazd Cardiovascular Research Center, Shahid Sadooghi University of Medical Science, Iran
  21. 21. Associate Perofessor of Cardiology, Zanjan University of Medical Sciences, Iran
  22. 22. Clinical Education Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  23. 23. Faculty of Medicine, School of Population and Public Health, University of British Columbia, Vancouver, Canada

Source: International Journal of Cardiology: Cardiovascular Risk and Prevention Published:2023


Abstract

Background: Statins use is the most important treatment for high LDL cholesterol in patients with premature coronary artery disease (CAD). Previous reports have shown racial and gender differences in statin use in the general population, but this wasn't studied in premature CAD based on different ethnicities. Methods and results: Our study includes 1917 men and women with confirmed diagnosis of premature CAD. Logistic regression model was used to evaluate the high LDL cholesterol control in the groups and the OR with 95% confidence interval (CI) was reported as the effect size. After adjustment for confounders, the odds of controlling LDL in women taking Lovastatin, Rosuvastatin, and Simvastatin were 0.27 (0.03, 0.45) lower in comparison with men. Also, in participant who took 3 types of statins, the odds of controlling LDL were significantly different between Lor and Arab compared with Fars ethnicity. After adjustment to all confounders (full model), the odds of controlling LDL were lower for Gilak in Lovastatin, Rosuvastatin, and Simvastatin by 0.64 (0.47, 0.75); 0.61 (0.43, 0.73); 0.63 (0.46, 0.74) respectively and higher for Arab in Lovastatin, Rosuvastatin, and Simvastatin by 4.63 (18.28, 0.73); 4.67 (17.47, 0.74); 4.55 (17.03, 0.71) respectively compared to Fars. Conclusions: Major differences in different gender and ethnicities may have had led to disparities in statin use and LDL control. Awareness of the statins impact on high LDL cholesterol based on different ethnicities can help health decision-makers to close the observed gaps in statin use and control LDL to prevent CAD problems. © 2023 The Authors
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