Association of High Level of Hs-Crp With In-Stent Restenosis: A Case-Control Study Publisher Pubmed



Baktashian M^{1, 2} ; Saffar Soflaei S^{1, 2} ; Kosari N² ; Salehi M³ ; Khosravi A⁴ ; Ahmadinejad M⁵ ; Moohebati M⁶ ; Ebrahimi M⁶ ; Rahmani F⁷ ; Khamenehbagheri R⁸ ; Ahmadi M⁸ ; Sadabadi F^{1, 2} ; Tayefi M^{9, 10} ; Bazhdanzadeh S¹¹ Show All Authors Show Affiliations
Source: Cardiovascular Revascularization Medicine Published:2019

Abstract

Background: In-stent restenosis (ISR) is one adverse outcome of coronary stent implantation. Although using drug-eluting stents has reduced the rate of ISR, it remains a major problem. Here, we have investigated the relationship between several patient characteristics including serum high sensitive C-reactive protein (hs-CRP) and ISR. Methods: This was a case-control study comprising 104 individuals with ISR and 202 patients without. Baseline characteristics were collected using a questionnaire. Fasting blood glucose (FBG), serum triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and serum high sensitivity C-reactive protein (hs-CRP) were measured using commercial kits on an auto-analyzer. Data were analyzed using SPSS software and a p value ≤ 0.05 was considered significant. Results: Diabetes mellitus (p < 0.001), stent type (p = 0.005), serum hs-CRP (p = 0.006), FBG (p = 0.038) and serum TG (p = 0.039) were significantly associated with ISR. The association between hs-CRP and ISR remained significant after adjustment for stent type and DM. For patients with a serum hs-CRP <2.64 mg/dL, ISR was only associated with diabetes mellitus (p = 0.016); while for individuals with a serum hs-CRP ≥2.64 mg/dL, ISR was also associated with the presence of diabetes mellitus, serum triglycerides and stent type. Conclusion: Higher levels of serum hs-CRP were significantly associated with the occurrence of ISR. © 2018 Elsevier Inc.