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Gastrointestinal and Renal Complications in Sars-Cov-2-Infected Patients: Role of Immune System Publisher Pubmed



Maghool F1 ; Valiani A2 ; Safari T3 ; Emami MH1 ; Mohammadzadeh S1
Authors
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Authors Affiliations
  1. 1. Poursina Hakim Digestive Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Anatomical Sciences, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Physiology, Zahedan University of Medical Sciences, Zahedan, Iran

Source: Scandinavian Journal of Immunology Published:2021


Abstract

The recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease has been accompanied by various gastrointestinal (GI) and renal manifestations in significant portion of infected patients. Beside studies on the respiratory complications of coronavirus infection, understanding the essential immunological processes underlying the different clinical manifestations of virus infection is crucial for the identification and development of effective therapies. In addition to the respiratory tract, the digestive and urinary systems are the major sources of virus transmission. Thus, knowledge about the invasion mechanisms of SARS-CoV-2 in these systems and the immune system responses is important for implementing the infection prevention strategies. This article presents an overview of the gut and renal complications in SARS-CoV-2 infection. We focus on how SARS-CoV-2 interacts with the immune system and the consequent contribution of immune system, gut, and renal dysfunctions in the development of disease. © 2020 The Scandinavian Foundation for Immunology
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