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Clinical Display, Diagnostics and Genetic Implication of Novel Coronavirus (Covid-19) Epidemic Publisher Pubmed



Forouzesh M1 ; Rahimi A2 ; Valizadeh R3, 4 ; Dadashzadeh N1 ; Mirzazadeh A5, 6
Authors
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Authors Affiliations
  1. 1. Specialist in Forensic Medicine, Assistant Professor of Forensic Medicine, Legal Medicine Research Center, Iranian Legal Medicine Organization, Tehran, Iran
  2. 2. Department of Genetics and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Student Research Committee, Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Nickan Research Institute, Isfahan, Iran
  5. 5. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  6. 6. Joint Bioinformatics Graduate Program, University of Arkansas Little Rock, University of Arkansas for Medical Sciences, Little Rock, AR, United States

Source: European Review for Medical and Pharmacological Sciences Published:2020


Abstract

COVID-19 pandemic can cause irreparable damage to the involved society. This study aimed to provide a summary of the up-to-dated clinical display, diagnostics, molecular and genetic implications for COVID-19 infected patients. In this review, 73 research articles published before 25 March 2020 were analyzed to better understand the clinical characteristics of patients and to introduce the available serological, hematology and molecular diagnostic methods. Apart from articles extracted from PubMed and Google Scholar, WHO (https://www.who. int/), NHC (National Health Commission of the People's Republic of China (http://www.nhc.gov. cn/), NICE (National Institute for Health and Clinical Excellence, https://www.nice.org.uk/), CDC (Centers for Disease Control and Prevention, https://www.cdc.gov/), and National Administration of Traditional Chinese Medicine (http://www. satcm.gov.cn/) were also accessed to search for eligible studies. Papers published between January 1, 2020, and 25 March 2020 were searched in English and the terms “2019-nCoV, Covid-19, Clinical Characteristics OR manifestation, method of detection, COVID-19 Genome and molecular test” were used. As the pandemic continues to evolve, there have been reports about the possibility of asymptomatic transmission of this newly emerged pneumonia virus. We highlighted the role of HLA haplotype in virus infection as HLA typing will provide susceptibility information for personalized prevention, diagnosis, and treatment in future studies. All the data in this article will assist researchers and clinicians to develop their clinical views regarding infected patients and to emphasize the origin of SARS-CoV-2 for diagnostics. © 2020 Verduci Editore s.r.l. All rights reserved.
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