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The Effects of High Fructose Fruits and Honey on the Serum Level of Metabolic Factors and Nonalcoholic Fatty Liver Disease Publisher



Sadeghi F1 ; Amanat S2 ; Bakhtiari M3 ; Asadimehr H4 ; Okhovat MA5 ; Hosseinzadeh M6 ; Mazloomi SM7 ; Gholamalizadeh M8 ; Doaei S9
Authors
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Authors Affiliations
  1. 1. Discipline of Physiotherapy, School of Medicine, Trinity College Dublin, Dublin, Ireland
  2. 2. Student Research Committee, Larestan University of Medical Sciences, Larestan, Iran
  3. 3. Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Larestan University of Medical Sciences, Larestan, Iran
  5. 5. Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  7. 7. Nutrition Research Center, Department of Food Hygiene and Quality Control, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
  8. 8. Student Research Committee, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  9. 9. Reproductive Health Research Center, Department of Obstetrics & Gynecology, Al-Zahra Hospital, School of Health, Guilan University of Medical Sciences, Rasht, Iran

Source: Journal of Diabetes and Metabolic Disorders Published:2021


Abstract

Introduction: The effect of the natural sources of fructose such as high fructose fruits and honey on the risk of fatty liver is still challenging. This study aimed to compare the effect of fructose, high fructose fruits, and honey on the metabolic factors and non-alcoholic fatty liver disease (NAFLD). Methods: Forty-four rats were divided into four groups including normal diet group, high fructose group (HF), high fructose fruits group (HFF), and honey group (HO). After 120 days of intervention, the levels of insulin resistance, hepatic enzyme, and lipid profile were measured. Also, the expression levels of the acetyl-coA carboxylase (ACC), sterol regulatory element-binding protein 1c (SREBP-1c), Interleukin 6 (IL-6), and transforming growth factor-beta (TGF-β) genes were assessed. In addition, a histopathologic assessment was performed on liver tissues. Results: Insulin resistance (IR) increased significantly in the HF, HFF, and HO groups (All P < 0.05). The levels of liver enzymes was significantly increased only in the group receiving the HF regimen (P < 0.01). A significant decrease in total cholesterol and HDL-C (high density lipoprotein cholesterol) levels was found in HO group compared to the control group (P < 0.05). The expression levels of ACC and SREBP-1c genes in HF, HFF, and HO groups were significantly higher than the control group (All P < 0.05). The HF group had a greater increase in the level of gene expression of IL-6 and TGF-β (All P < 0.05). Histopathological assessment did not find any changes in fatty liver formation and inflammatory damage. Conclusion: Consumption of fructose-rich honey and fruits improved the status of inflammatory markers and liver enzymes compared with the industrial fructose-rich products. © 2021, Springer Nature Switzerland AG.
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