Fabrication and Characterization of Pcl/Gel Nanofibrous Scaffolds Incorporated With Graphene Oxide Applicable in Cardiac Tissue Engineering Publisher

Summary: Study shows graphene oxide scaffolds enhance cell growth. Could this aid tissue repair? #TissueEngineering #Nanotechnology

Fakhrali A¹ ; Poursharifi N¹ ; Nasari M¹ ; Semnani D¹ ; Salehi H² ; Ghane M¹ ; Mohammadi S³
Source: Polymer-Plastics Technology and Materials Published:2021

Abstract

Herein, we fabricated poly (caprolactone)/Gelatin (PCL/Gel) nanofibrous scaffolds and graphene oxide (GO 0.3, 0.6 and 1% w/w) was incorporated into scaffolds. Morphological, structural, mechanical and in vitro analyses of the samples were performed. The diameter of PCL nanofibers was increased by adding Gel and GO, especially by adding 1%w/w of GO (210 ± 20 nm versus 482 ± 104 nm). Mechanical properties and hydrophilicity were improved. All scaffolds were nontoxic and the most biocompatibility values obtained were 91.71 ± 0.1% and 94.29 ± 1.1%, which were related to PCL/Gel and PCL/Gel/GO0.3, respectively. Among all samples, PCL/Gel/GO0.3 showed the highest cell area (0.973 ± 0.041). © 2021 Taylor & Francis.