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Stem Cell- and Gene-Based Therapies As Potential Candidates in Alzheimer's Therapy Publisher Pubmed



Hosseini SA1 ; Mohammadi R1 ; Noruzi S1 ; Mohamadi Y2 ; Azizian M4 ; Mousavy SM5 ; Ghasemi F6 ; Hesari A6 ; Sahebkar A7, 8 ; Salarinia R1 ; Aghdam AM9 ; Mirzaei H10
Authors
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Authors Affiliations
  1. 1. Department of Medical Biotechnology and Molecular Sciences, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
  2. 2. Department of Anatomy, Faculty of medicine, Tehran university of medical sciences, Tehran, Iran
  3. 3. Department of Anatomy, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
  4. 4. Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran
  5. 5. Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Biotechnology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
  7. 7. Biotechnology Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  9. 9. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  10. 10. Department of Biomaterials, Tissue Engineering and Nanotechnology, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Cellular Biochemistry Published:2018


Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder, which is associated with impairments of memory, thinking, language, and reasoning. Despite extensive research aiming at the treatment of AD, durable and complete remissions are rare. Hence, new therapeutic approaches are required. Among various therapeutic approaches, stem cells (ie, neural stem cells, mesenchymal stem cells, and embryonic stem cells) and delivery of protective genes such as encoding nerve growth factor, APOE, and glial cell–derived neurotrophic factor have generated promise in AD therapy. Here, we summarized a variety of effective therapeutic approaches (ie, stem cells, and genes) in AD therapy. © 2018 Wiley Periodicals, Inc.
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