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Effect of Serum Magnesium Levels on Outcomes of Patients Hospitalized With Covid-19 Publisher Pubmed



Dana N1 ; Vaseghi G2 ; Nasirian M3 ; Laher I4 ; Manteghinejad A5 ; Mosayebi A1 ; Javanmard SH1
Authors
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Authors Affiliations
  1. 1. Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Epidemiology and Biostatistics, Health School, Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
  5. 5. Department of Oncology, Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Bratislava Medical Journal Published:2023


Abstract

BACKGROUND: The coronavirus disease 2019 (COVID-19) causes acute respiratory illness and multiorgan failure. The critical roles of magnesium in human health suggest that it could have an active role in the prevention and treatment of COVID-19. We measured magnesium levels in hospitalized COVID-19 patients concerning disease progression and mortality. MATERIALS AND METHODS: This study was conducted in 2321 hospitalized COVID-19 patients. Clinical characteristics from each patient were recorded, and blood samples were collected from all patients upon their fi rst admission to the hospital to determine serum magnesium levels. Patients were divided into two groups based on discharge or death. The effects of magnesium on death, severity, and hospitalization duration were estimated by crude and adjusted odds ratio using Stata Crop (version 12) software. RESULTS: Mean magnesium levels in patients who died were higher than in discharged patients (2.10 vs 1.96 mg/dl, p < 0.0001). Among patients who died, 13.4 % had low, 66.1 % normal, and 20.6 % high magnesium levels. Of admitted patients with COVID-19, 61.1 % had at least one additional disorder. Magnesium defi ciency was unrelated to death or duration of hospitalization (p > 0.05). CONCLUSIONS: We found no relation between hypomagnesaemia on COVID-19 progression, although hypermagnesaemia could affect COVID-19 mortality (Tab. 4, Ref. 34) © 2023, Bratislava Medical Journal.All Rights Reserved.
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