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Diterpenoids From Euphorbia Gedrosiaca As Potential Anti-Proliferative Agents Against Breast Cancer Cells Publisher



Yazdiniapour Z1 ; Sohrabi MH1 ; Motinia N1 ; Zolfaghari B1 ; Mehdifar P1 ; Ghanadian M1 ; Lanzotti V2
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Authors Affiliations
  1. 1. Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  2. 2. Dipartimento di Agraria, Universita di Napoli Federico II, Napoli, Portici, 80055, Italy

Source: Metabolites Published:2023


Abstract

Isolated diterpenes from various species of Euphorbia are important compounds for drug discovery with a broad spectrum of structures and biological effects. In this study, Euphorbia gedrosiaca, one of the endemic species of Iran, was analyzed in terms of the presence and structural determination of diterpenoid compounds. They were extracted with dichloromethane/acetone (2:1) from aerial parts of this plant and purified by chromatographic methods such as MPLC and HPLC. Four premyrsinane compounds and one myrsinane diterpene were isolated from Euphorbia gedrosiaca. They were characterized by extensive 1D and 2D NMR and HRMS analyses. Additionally, their activities were evaluated against two breast cancer cell lines, MDA-MB-231 and MCF-7, by MTT proliferation assay. They exhibited cytotoxic effects in a dose-dependent manner with promising results, which can help to find possible therapeutic application of diterpenoids in breast cancer treatment. © 2023 by the authors.
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