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Convenient Synthesis of Novel Chalcone and Pyrazoline Sulfonamide Derivatives As Potential Antibacterial Agents Publisher



Bonakdar APS1 ; Sadeghi A1 ; Aghaei HR1 ; Beheshtimaal K2 ; Nazifi SMR3 ; Massah AR1
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Shahreza Branch, Islamic Azad University, Shahreza, 86145-311, Iran
  2. 2. Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Falavarjan, Iran
  3. 3. Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran

Source: Russian Journal of Bioorganic Chemistry Published:2020


Abstract

Abstract: Novel chalcone sulfonamide derivatives were synthesized starting from benzophenones and aldehydes in 3 steps. Also, (E)-3-(4-chlorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one was converted to different pyrazoline in four steps. The synthesis of sulfonamides was carried out under solvent-free conditions at room temperature and the products were obtained in high purity after a simple work-up without using any chromatography method for purification. All of the products were evaluated for their in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli. © 2020, Pleiades Publishing, Ltd.
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