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Synthesis, Molecular Docking Studies, and Absorption, Distribution, Metabolism, and Excretion Prediction of Novel Sulfonamide Derivatives As Antibacterial Agents Publisher



Mohebali F1 ; Nazifi Z1, 2 ; Mohamad Reza Nazifi S3 ; Mohammadian H4 ; Massah AR1, 2
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Shahreza Branch, Islamic Azad University, Isfahan, Iran
  2. 2. Razi Chemistry Research Center, Shahreza Branch, Islamic Azad University, Isfahan, Iran
  3. 3. Department Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of the Chinese Chemical Society Published:2019


Abstract

A series of novel sulfonamide-amide derivatives were synthesized from 3-(2,4 dichlorophenylamino)-3-oxopropane-1-sulfonylchloride and a variety of amines under solvent-free conditions at room temperature. 3-(2,4-dichlorophenylamino)-3-oxopropane-1 sulfonylchloride was synthesized in four steps starting from 2,4-dichloroaniline and chloropropanoic acid in good yield and purity. The synthesized compounds were screened for their in vitro antibacterial activity against Escherichia coli (ATCC 25922) and Staphylococcus aureus (ATCC 29213). Molecular docking of sulfonamide derivatives into S. aureus tyrosyl-tRNA synthetase (TyrRS)-active site was also performed and among these, 5m and 5g tightly fit the active sites that might be inhibitors of TyrRS for further investigations. Also in the silico metabolism profile, drug-like properties and absorption, distribution, metabolism, excretion and toxicity (ADMET) of the title compounds were calculated by the preADMET server. © 2019 The Chemical Society Located in Taipei & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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