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Hemoperfusion in Patients With Severe Covid-19 Respiratory Failure, Lifesaving or Not? Publisher



Abbasi S1 ; Naderi Z2 ; Amra B3 ; Atapour A4 ; Dadkhahi S2 ; Eslami M5 ; Hajian M5 ; Hashemi M6 ; Hashemi S7 ; Iraj B8 ; Khorvash F9 ; Madadi S10 ; Pour H11 ; Mansourian M12 Show All Authors
Authors
  1. Abbasi S1
  2. Naderi Z2
  3. Amra B3
  4. Atapour A4
  5. Dadkhahi S2
  6. Eslami M5
  7. Hajian M5
  8. Hashemi M6
  9. Hashemi S7
  10. Iraj B8
  11. Khorvash F9
  12. Madadi S10
  13. Pour H11
  14. Mansourian M12
  15. Rezvani M13
  16. Sami R14
  17. Soltaninejad F15
  18. Shahidi S4
  19. Vahdat S4
  20. Zamani Z4
  21. Moeinzadeh F4
Show Affiliations
Authors Affiliations
  1. 1. Anesthesiology and Critical Care Research Center, Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pulmonology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Bamdad Respiratory Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Sofe Ave., Isfahan, Iran
  5. 5. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Pulmonology, Amin Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Department of Internal Medicine, Endocrine and Metabolism Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. Acquired Immunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  10. 10. Khatamolanbia Natanz Regional Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  11. 11. Department of Anesthesiology and Critical Care Medicine, Critical Care Research Center, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
  12. 12. Department of Epidemiology and Biostatics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  13. 13. Department of Neurosurgery, Neuroscience Research Center, School of Medicine, Al Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  14. 14. Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  15. 15. Respiratory Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Research in Medical Sciences Published:2021


Abstract

Background: The new coronavirus outbreak quickly filled hospital beds and stunned the world. Intensive care is required for 5% of patients, and the mortality rate for critically ill patients is 49%. The 'cytokine storm' is considered as the main cause of pathogenesis for coronavirus disease-19 (COVID-19)-related respiratory failure, hemoperfusion may be a modality for treatment of disease. Materials and Methods: Thirty-seven an patients with positive real-time polymerase chain reaction for SARStions2 in an upper respiratory tract sample or typical chest computed tomography lesion were eligible for this case-control study. Patients meeting the criteria for hemoperfusion including clinical and laboratory indices, were evaluated for outcomes such as hospitalization length and mortality. Patients were divided into three groups, i.e., patients who received hemoperfusion without a need for mechanical ventilation (MV), patients who received hemoperfusion before MV, and patients who received hemoperfusion after MV. Results: Among 37 patients with COVID-19 respiratory failure, 32% were female with a mean age of 55.54 (standard deviation 14.1) years. There was no statistically significant difference between the three groups in terms of length of hospital stay and intensive care unit (ICU) stay (P-tayns: 0.593 and 0.243, respectively, confidence interval [CI]: 95%). Heart rate, respiratory rate, PaO 2 /FIO 2, high-sensitivity C-reactive protein, and ferritin significantly improved after the application of hemoperfusion in all groups (P < 0.05, CI: 95%). Conclusion: It seems that applying hemoperfusion in the inflammatory phase of the disease, especially before the intubation, reduce the need for MV. However, hemoperfusion does not have any impacts on the duration of hospital and ICU stay. © 2021 Journal of Research in Medical Sciences.
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