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The Effect of Ultrasound Parameters on the Destruction of 4T1 Cells in the Presence of Gold Nanoparticles Publisher



Shanei A1 ; Salamat MR1 ; Hejazi H2 ; Mirzaeiyan M1
Authors
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Authors Affiliations
  1. 1. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2018


Abstract

Background: The ultrasound parameters such as intensity and time of radiation play an important role in cellular degradation. In this study, the effect of ultrasound radiation parameters on the degradation of 4T1 cells in the presence of gold nanoparticles was investigated. Methods: The 4T1 cells were cultured. The cells were divided into 4 groups including control, gold nanoparticle, ultrasound alone, and ultrasound at the presence of gold nanoparticle. Ultrasound irradiation were performed on the cells at intensity of 0.5, 1.0, and 1.5 W/cm2, for 1, 1.5, and 2 minutes. The viability of cells was determined using MTT assay. Findings: There was a significant difference in cell viability between the ultrasound and gold nanoparticle group and the other groups at intensity of 1.0 and 1.5 W/cm2. Moreover, there was a significant difference between the ultrasound alone and the control groups at intensity of 1.0 and 1.5 W/cm2. Conclusion: Using ultrasound in the presence of gold nanoparticles increase cell death via increasing nuclei cavitation phenomenon. © 2018, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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