Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Therapeutic Effects of Acoustic Cavitation in the Presence of Gold Nanoparticles on a Colon Tumor Model Publisher Pubmed



Sazgarnia A1, 5 ; Shanei A1 ; Taheri AR2 ; Meibodi NT3 ; Eshghi H4 ; Attaran N4 ; Shanei MM6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Research Center and Department of Medical Physics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Department of Dermatology, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Department of Research Center, Pathology, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Chemistry, School of Science, Ferdowsi University of Mashhad, Mashhad, Iran
  5. 5. Department of Medical Physics and Medical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan 91779 48564, Darvaze Shiraz Boulevard, Iran
  6. 6. Department of Nanoscience and Nanotechnology, Kashan University, Kashan, Iran

Source: Journal of Ultrasound in Medicine Published:2013


Abstract

Objectives: Acoustic cavitation can be fatal to cells and is used to destroy cancerous tumors. The particles in a liquid decrease the ultrasonic intensity threshold needed for onset of cavitation. Bubble generation from intense pulsed light-irradiated gold nanoparticles was investigated as a means of providing nucleation sites for acoustic cavitation in cancer tissues. Methods: This study was conducted on colon carcinoma tumors in BALB/c mice. The tumor-bearing mice were randomly divided into 7 groups (each containing 15 mice): (1) control, (2) gold nanoparticles, (3) intense pulsed light irradiation, (4) intense pulsed light + gold nanoparticles, (5) ultrasound alone, (6) ultrasound + gold nanoparticles, and (7) intense pulsed light + ultrasound + gold nanoparticles. In the respective groups, gold nanoparticles were injected into tumors. Intense pulsed light and ultrasound irradiation were performed on the tumors 24 hours after injection. Antitumor effects were estimated by evaluation of the relative tumor volume, doubling time, and 5-folding time for tumors after treatment. The cumulative survival fraction of the mice and percentage of the lost tissue volume (treated) were also assessed in different groups. Results: A significant difference in the average relative tumor volumes 15 days after treatment was found between the intense pulsed light + ultrasound + gold nanoparticle group and the other groups (P <.05). The longest doubling and 5-folding times were observed in the intense pulsed light + ultrasound + gold nanoparticles and ultrasound + gold nanoparticle groups. Conclusions: Acoustic cavitation in the presence of gold nanoparticles and intense pulsed light has been introduced as a new way for improving therapeutic effects on tumors by reducing the relative tumor volume and increasing the cumulative survival fraction. © 2013 by the American Institute of Ultrasound in Medicine.
Related Docs
View other Related Docs
1. An Overview of Therapeutic Applications of Ultrasound Based on Synergetic Effects With Gold Nanoparticles and Laser Excitation, Iranian Journal of Basic Medical Sciences (2019)
2. Monitoring of Transient Cavitation Induced by Ultrasound and Intense Pulsed Light in Presence of Gold Nanoparticles, Ultrasonics Sonochemistry (2014)
3. Destructive Effects of Therapeutic Ultrasound and Gold Nanoparticles on a Breast Carcinoma Tumor Model in Balb/C Mice, International Journal of Radiation Research (2020)
4. A Novel Nanosonosensitizer for Sonodynamic Therapy: In Vivo Study on a Colon Tumor Model, Journal of Ultrasound in Medicine (2011)
5. Nanoparticles on a Breast Carcinoma Tumor Model in Balb/C Mice, International Journal of Radiation Research (2020)
6. Sonodynamic Therapy Using Protoporphyrin Ix Conjugated to Gold Nanoparticles: An in Vivo Study on a Colon Tumor Model, Iranian Journal of Basic Medical Sciences (2012)
7. Effect of Gold Nanoparticle Size on Acoustic Cavitation Using Chemical Dosimetry Method, Ultrasonics Sonochemistry (2017)
8. Effect of Targeted Gold Nanoparticles Size on Acoustic Cavitation: An in Vitro Study on Melanoma Cells, Ultrasonics (2020)
Experts (# of related papers)
View all Related Experts
Ahmad Shanei (28)
Seyed Hossein Hejazi (9)
Other Related Docs
9. Detection of Sonoluminescence Signals in a Gel Phantom in the Presence of Protoporphyrin Ix Conjugated to Gold Nanoparticles, Ultrasonics (2013)
10. Evaluation of Acoustic Cavitation in Terephthalic Acid Solutions Containing Gold Nanoparticles by the Spectrofluorometry Method, International Journal of Photoenergy (2012)
11. Evaluation of Sonochemiluminescence in a Phantom in the Presence of Protoporphyrin Ix Conjugated to Nanoparticles, Iranian Journal of Medical Physics (2012)
12. Cancerous Cell Destruction Using Low Level Ultrasound in the Presence of Gold Nanoparticles: An in Vitro Study on 4T1 Cells, Current Nanoscience (2018)
13. The Effect of Ultrasound Waves on Melanoma Cells in Presence of Gold Nanoparticles, Journal of Isfahan Medical School (2017)
14. The Effect of Ultrasound Parameters on the Destruction of 4T1 Cells in the Presence of Gold Nanoparticles, Journal of Isfahan Medical School (2018)
15. The Effect of Ultrasound Therapy in the Presence of Combined Zinc Oxide/Gold Nanocomposite on Melanoma Cell Line, Journal of Isfahan Medical School (2023)
16. The Role of Gold Nanoparticles in Sonosensitization of Human Cervical Carcinoma Cell Line Under Ultrasound Irradiation: An in Vitro Study, Journal of Nano Research (2019)
17. Bystander Effect of Sonodynamic Therapy in the Presence of Gold Nanoparticles: An In-Vitro Study, International Journal of Radiation Research (2023)
18. Evaluating the Effects of Ultrasound Waves on Mcf-7 Cells in the Presence of Ag Nanoparticles, Journal of Isfahan Medical School (2016)
19. In Vitro Study of Sonodynamic Therapy Using Gemcitabine-Loaded Peg-Gold Nanoparticles Against Mcf-7 Breast Cancer Cells, BioNanoScience (2024)
20. The Effect of Ultrasound Exposure in Combination With Gold Nanoparticles on Colonization of A375 and Mcf-7 Bystander Cells, Journal of Isfahan Medical School (2021)
21. Dual Function of Gold Nanoparticles in Synergism With Mitoxantrone and Microwave Hyperthermia Against Melanoma Cells, Asian Pacific Journal of Cancer Prevention (2017)
22. Synergistic Effect of the Combination of Triethylene-Glycol Modified Fe3o4 Nanoparticles and Ultrasound Wave on Mcf-7 Cells, Journal of Magnetism and Magnetic Materials (2015)
23. The Effect of Bystander Due to Combined Treatment of Ultrasound Waves and Cisplatin on Melanoma A375 Cell Line, Journal of Isfahan Medical School (2021)
24. Au Nanoparticles in the Diagnosis and Treatment of Ovarian Cancer: A New Horizon in the Personalized Medicine, Nanomedicine Research Journal (2022)
25. As1411 Aptamer-Targeted Gold Nanoclusters Effect on the Enhancement of Radiation Therapy Efficacy in Breast Tumor-Bearing Mice, Nanomedicine (2018)
26. Investigating the Sonodynamic-Radiosensitivity Effect of Gold Nanoparticles on Hela Cervical Cancer Cells, Journal of Korean Medical Science (2019)
27. Effects of Radiofrequency Radiation in the Presence of Gold Nanoparticles for the Treatment of Renal Cell Carcinoma, Journal of Renal Injury Prevention (2017)
28. Bystander Effect of Therapeutic Ultrasound in the Presence of Cisplatin: An in Vitro Study on Human Melanoma Cells, Journal of Biomedical Physics and Engineering (2023)
29. Optical, Physical and Quantum Properties of Gold Nanoparticles and Its Applications in Diagnosis and Treatment of Cancers, Journal of Isfahan Medical School (2015)
30. The Effect of Folic Acid-Targeted Nanocarriers in Ultrasound Imaging-Guided Sonodynamic Therapy of Human Cervical Carcinoma (Hela): In Vitro Study, Koomesh (2023)
31. Recent Advances in Improved Efficacies of Gold Nano-Formulations in Treatment of Skin Cancer: A Systematic Review, Archives of Dermatological Research (2025)
32. As1411 Aptamer Conjugated Gold Nanoclusters As a Targeted Radiosensitizer for Megavoltage Radiation Therapy of 4T1 Breast Cancer Cells, RSC Advances (2018)
33. Induction of a Bystander Effect After Therapeutic Ultrasound Exposure in Human Melanoma: In-Vitro Assay, International Journal of Radiation Research (2021)
34. Targeted Photothermal Therapy of Melanoma in C57bl/6 Mice Using Fe3 O4 @Au Core-Shell Nanoparticles and Near-Infrared Laser, Journal of Biomedical Physics and Engineering (2021)
35. Gold Nanostructures in Medicine and Biology, Nanoparticles in Medicine (2019)
36. Anti-Cd24 Bio Modified Pegylated Gold Nanoparticles As Targeted Computed Tomography Contrast Agent, Advanced Pharmaceutical Bulletin (2018)
37. Gold Nanoparticle and Mean Inactivation Dose of Human Intestinal Colon Cancer Ht-29 Cells, Jundishapur Journal of Natural Pharmaceutical Products (2015)
38. Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review, Diagnostics (2023)
39. In Vitro Investigation of Radiotherapy Along With Gemcitabine Loaded Peg Gold Nanoparticles Against Mcf-7 Breast Cancer Cells, Advanced Biomedical Research (2025)