The Effect of Ultrasound Waves on Melanoma Cells in Presence of Gold Nanoparticles



Shanei A¹ ; Baradaran M¹ ; Shanei MM²
Source: Journal of Isfahan Medical School Published:2017

Abstract

Background: Biological effects of ultrasound waves and their applications in the presence of nanoparticles are a rapidly growing research area. In recent years, ultrasonic therapy of cancer cells has been developed successfully. In this study, effects of ultrasound waves in the presence of gold nanoparticles on the melanoma cells were evaluated. Methods: The Melanoma cells were cultured and divided into 4 groups of control, gold nanoparticle, ultrasound alone and ultrasound waves at the presence of gold nanoparticle. Ultrasound irradiation at intensity of 2 W/cm2 was performed on the cells for 3 minutes. Findings: There was a significant difference in the percent of cell viability between the ultrasound + gold nanoparticles and the other groups. In addition, there was a significant difference between the ultrasound and the control groups, too. Conclusion: Results of this study reveal that ultrasound in the presence of gold nanoparticles can be efficiently used for treatment of melanoma cells; as gold nanoparticles act as cavitation nuclei. © 2017, Isfahan University of Medical Sciences(IUMS). All rights reserved.