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Cytotoxicity Evaluation of 63S Bioactive Glass Nanoparticles by Microcalorimetry Publisher



Doostmohammadi A1 ; Monshi A1 ; Fathi MH1 ; Braissant O2 ; Daniels AU2
Authors
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Authors Affiliations
  1. 1. Biomaterials Group, Materials Engineering Department, Isfahan University of Technology, Isfahan 84156-83111, Iran
  2. 2. Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran

Source: Ceramic Transactions Published:2012


Abstract

The cytotoxicity evaluation of 63S bioactive glass nanoparticles with yeast and human chondrocyte cells was carried out using isothermal micro-nano calorimetry (IMNC). Bioglass nanoparticles were made via sol-gel method. Elemental analysis was carried out by XRF. Amorphous structure of the glass was detected by XRD analysis. Finally, the cytotoxicity of bioactive glass nanoparticles with yeast and cultured human chondrocyte cells was evaluated using IMNC. The results confirmed the viability and proliferation of human chondrocyte cells in contact with 63S bioglass nanoparticles. Also the results indicated that yeast model which is much easier to handle, can be considered as a good proxy and can provide a rapid primary estimate of the ranges to be used in assays involving human cells. All of these results confirmed that IMNC is a convenient method which caters to measuring the cell-biomaterial interactions alongside the current methods.
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