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Subcutaneous Connective Tissue Reactions to Three Types of Bioactive Glass Nanopowders Publisher Pubmed



Mehdikhaninahrkhalaji M1, 2 ; Fathi MH1 ; Mortazavi V2 ; Mousavi SB3 ; Razavi SM4
Authors
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Authors Affiliations
  1. 1. Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan, 8415683111, Iran
  2. 2. Department of Operative Dentistry and Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran
  3. 3. Department of Endodontics and Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran
  4. 4. Department of Oral and Maxillofacial Pathology and Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran

Source: Journal of Biomedical Nanotechnology Published:2011


Abstract

Silica-based bioactive glasses are considered promising bone substitutes and tissue regeneration matrices, because of their bioactivity, biocompatibility, osteoconductivity, and possibly even osteoinductivity. The aim of this work was to evaluate the subcutaneous connective tissue reactions to 58S, 63S, and 72S bioactive glass nanopowders. Our previous study showed the antibacterial activities of 58S and 63S bioactive glass nanopowders on aerobic bacteria, while 72S showed no antibacterial effects at all. Bioactive glass nanopowders were prepared via the sol-gel technique. Characterization techniques such as X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), and X-ray fluorescent (XRF) were utilized to carry out the phase analysis, study of the structure, particle size and the composition of the synthesized bioactive glasses. To evaluate the subcutaneous connective tissue reactions, the specimens were placed in polyethylene tubes and implanted into the dorsal connective tissue of rats. Empty polyethylene tubes were used as the control and bioactive glass micropowders (NovaBone®) was used as a FDA approved bone graft. The evaluation of inflammatory reactions was performed 3, 7, 15, and 28 days after implantation. Results showed a particle size of below 100 nm for samples with amorphous structure. The samples were well tolerated by the tissues over a 28-day evaluation period. The extra tissue reactions of the 72S specimen in comparison with 58S and 63S specimens could be attributed to its higher silica content. It may be concluded that biocompatible 58S and 63S bioactive glass nanopowders with antibacterial activities can be synthesized for the treatment of osseous defects. Copyright © 2011 American Scientific Publishers All rights reserved.
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