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Biocompatibility Evaluation of Bioglass Nanoparticles to Chondrocyte Cells by Isothermal Microcalorimetry Publisher



Doostmohammadi A1 ; Monshi A1 ; Fathi MH1 ; Salehi R2 ; Karbasi S3 ; Braissant O4 ; Daniels AU4
Authors
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Authors Affiliations
  1. 1. Biomaterials Group, Materials Engineering Department, Isfahan University of Technology (IUT), Isfahan, Iran
  2. 2. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
  3. 3. Biomedical Engineering Department, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
  4. 4. Laboratory of Biomechanics and Biocalorimetry, Faculty of Medicine, University of Basel, Basel, Switzerland

Source: 2010 17th Iranian Conference of Biomedical Engineering, ICBME 2010 - Proceedings Published:2010


Abstract

This study aimed at the biocompatibility evaluation of bioglass nanoparticles to chondrocyte cells using isothermal micro/nano calorimetry (IMNC), which is a new method to study cell/biomaterial interactions. For this purpose, 63S bioglass nanoparticles were made via sol-gel method and primary characterization was carried out on the particles. XRD analysis showed the amorphous structure of the glass and the particle size and morphology were investigated by SEM. Finally the bioglass nanoparticles' biocompatibility with yeast and cultured human chondrocyte cells was evaluated using IMNC. The results showed no deleterious effect on chondrocyte growth and they can grow, proliferate and live on beside bioglass nanoparticles. In another word, the obtained results from this study confirmed the growth, proliferation and viability of chondrocyte cells close to 63S bioactive glass nanoparticles at low concentrations. © 2010 IEEE.
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