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Role of Insulin in Cognitive Functions of the Central Nervous System



Davari S1 ; Reisi P2
Authors
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Authors Affiliations
  1. 1. Department of Physiology, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Biosensor Research Center, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2013

Abstract

It was previously believed that insulin only has environmental performance and is not capable of crossing the blood-brain barrier or affecting the central nervous system. However, it is now clear that insulin and its receptors are present in the central nervous system. This hormone not only passes the blood-brain barrier, but may also be synthesized by neurons in the brain. As a neuropeptide, insulin is involved in the development and function of the nervous system. Deficiency of this hormone or dysfunction of its central receptors causes serious damage to cognitive processes including learning and memory. Such effects might be due to the non-metabolic effects of insulin. This study reviewed the role of insulin in neuronal processes.
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