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Effects of Treadmill Running on Spatial Learning and Memory in Streptozotocin-Induced Diabetic Rats Publisher Pubmed



Reisi P1 ; Alaei H1 ; Babri S2, 3 ; Sharifi MR1 ; Mohaddes G4
Authors
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Authors Affiliations
  1. 1. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Laboratory of Physiology, Drug Applied Research Center, Tabriz University (Medical Sciences), Tabriz, Iran
  3. 3. Neurosciences Research Center, Tabriz University (Medical Sciences), Tabriz, Iran
  4. 4. Department of Physiology, School of Medicine, Tabriz University (Medical Sciences), Tabriz, Iran

Source: Neuroscience Letters Published:2009


Abstract

Previous studies have shown an association between diabetes mellitus and impairments in learning and memory. These deficits were partially reversed by the use of insulin. Due to the fact that exercise has positive effects on many physiological systems, including the central nervous system, the present study, evaluated the effects of treadmill running on spatial learning and memory in streptozotocin (STZ)-induced diabetic rats. The exercise program was treadmill running at 17 meters per minute (m/min) at 0° inclination for 40 minutes per day (min/day), 7 days/week, for 12 weeks. Experimental groups were: the control-rest, the control-exercise, the diabetes-rest and the diabetes-exercise. Spatial learning and memory was investigated by Morris water maze test in the rats after 12 weeks of diabetes induction and the exercise period. Our data showed that spatial learning and memory was significantly impaired in the diabetes-rest group with respect to the control-rest group. However, there were no differences between the other groups. The present results suggest that spatial learning and memory is affected under diabetic conditions and that treadmill running prevents these effects. The data correspond to the possibility that treadmill running is helpful in the prevention and alleviation of the cognitive decline in diabetes mellitus. © 2009 Elsevier Ireland Ltd. All rights reserved.
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