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Cisplatin-Induced Renal Toxicity: A Short Review



Nasri H1 ; Baradaranghahfarokhi M2 ; Rafieiankopaie M3
Authors
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Authors Affiliations
  1. 1. Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Medical Physics and Medical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

Source: Life Science Journal Published:2014

Abstract

Cisplatin is an antineoplastic agent widely used in chemotherapy of ovarian, lung, bladder, breast, head and neck, and testicular cancers. However, its clinical use was rapidly limited due to unexpected and very severe renal toxicity and effective cancer chemotherapy with this agent has been further complicated by the lack of information concerning the mode of action and the species responsible for eliciting the anticancer activity. In this regard, acute and cumulative renal toxicity associated with histological damage has been shown in both animal and human studies. The present review includes a brief discussion of the nature and underlying mechanism of cisplatininduced nephrotoxicity. © 2014 Zhengzhou University. All Rights reserved.
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