Cisplatin-Induced Renal Toxicity: A Short Review



Nasri H¹ ; Baradaranghahfarokhi M² ; Rafieiankopaie M³
Source: Life Science Journal Published:2014

Abstract

Cisplatin is an antineoplastic agent widely used in chemotherapy of ovarian, lung, bladder, breast, head and neck, and testicular cancers. However, its clinical use was rapidly limited due to unexpected and very severe renal toxicity and effective cancer chemotherapy with this agent has been further complicated by the lack of information concerning the mode of action and the species responsible for eliciting the anticancer activity. In this regard, acute and cumulative renal toxicity associated with histological damage has been shown in both animal and human studies. The present review includes a brief discussion of the nature and underlying mechanism of cisplatininduced nephrotoxicity. © 2014 Zhengzhou University. All Rights reserved.