Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications Publisher



Assadpour E1, 2 ; Rezaei A3 ; Das SS4, 5 ; Krishna Rao BV4 ; Singh SK4 ; Kharazmi MS6 ; Jha NK7, 8 ; Jha SK7, 9, 10 ; Prieto MA11 ; Jafari SM11, 12, 13
Authors
Show Affiliations
Authors Affiliations
  1. 1. Food Industry Research Co, Gorgan, 49138-15739, Iran
  2. 2. Food and Bio-Nanotech International Research Center (Fabiano), Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, 49138-15739, Iran
  3. 3. Department of Food Science and Technology, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  4. 4. Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, India
  5. 5. School of Pharmaceutical and Population Health Informatics, DIT University, Dehradun, 248009, India
  6. 6. Faculty of Medicine, University of California, Riverside, 92679, CA, United States
  7. 7. Department of Biotechnology, School of Engineering and Technology (SET), Sharda University, Greater Noida, 201310, India
  8. 8. School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, 144411, India
  9. 9. Department of Biotechnology Engineering and Food Technology, Chandigarh University, Mohali, 140413, India
  10. 10. Department of Biotechnology, School of Applied and Life Sciences (SALS), Uttaranchal University, Dehradun, 248007, India
  11. 11. Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, Universidade de Vigo, Ourense, E-32004, Spain
  12. 12. Department of Food Materials and Process Design Engineering, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, 49189-43464, Iran
  13. 13. College of Food Science and Technology, Hebei Agricultural University, Baoding, 071001, China

Source: Pharmaceuticals Published:2023


Abstract

Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa, exhibits diverse pharmacological actions. However, the applications of CBD are restricted mainly due to its poor oral bioavailability. Therefore, researchers are focusing on the development of novel strategies for the effective delivery of CBD with improved oral bioavailability. In this context, researchers have designed nanocarriers to overcome limitations associated with CBD. The CBD-loaded nanocarriers assist in improving the therapeutic efficacy, targetability, and controlled biodistribution of CBD with negligible toxicity for treating various disease conditions. In this review, we have summarized and discussed various molecular targets, targeting mechanisms and types of nanocarrier-based delivery systems associated with CBD for the effective management of various disease conditions. This strategic information will help researchers in the establishment of novel nanotechnology interventions for targeting CBD. © 2023 by the authors.
Related Docs
1. Differentiating Cannabis Products: Drugs, Food, and Supplements, Frontiers in Pharmacology (2022)
2. Nanostructured Lipid Carriers (Nlc): A Potential Delivery System for Bioactive Food Molecules, Innovative Food Science and Emerging Technologies (2013)
3. Dendrimers As Nanoscale Vectors: Unlocking the Bars of Cancer Therapy, Seminars in Cancer Biology (2022)
4. Lipoprotein Like Nanoparticles Used in Drug and Gene Delivery, Current Pharmaceutical Design (2016)
5. Plant-Derived Edible Nanoparticles and Mirnas: Emerging Frontier for Therapeutics and Targeted Drug-Delivery, ACS Sustainable Chemistry and Engineering (2019)
6. The Strengths and Limits of Cannabinoids and Their Receptors in Cancer: Insights Into the Role of Tumorigenesis-Underlying Mechanisms and Therapeutic Aspects, Biomedicine and Pharmacotherapy (2021)
7. Targeting Etoposide to Acute Myelogenous Leukaemia Cells Using Nanostructured Lipid Carriers Coated With Transferrin, Nanotechnology (2012)
8. The Uniqueness of Albumin As a Carrier in Nanodrug Delivery, Molecular Pharmaceutics (2021)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (3)
Sedigheh Asgary (1)