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Dendrimers As Nanoscale Vectors: Unlocking the Bars of Cancer Therapy Publisher Pubmed



Dey AD1 ; Bigham A2 ; Esmaeili Y3 ; Ashrafizadeh M4, 5 ; Moghaddam FD6 ; Tan SC7 ; Yousefiasl S8 ; Sharma S1 ; Maleki A9, 10, 11 ; Rabiee N12, 13 ; Kumar AP14, 15 ; Thakur VK16, 17, 18 ; Orive G19, 20, 21 ; Sharifi E22, 23 Show All Authors
Authors
  1. Dey AD1
  2. Bigham A2
  3. Esmaeili Y3
  4. Ashrafizadeh M4, 5
  5. Moghaddam FD6
  6. Tan SC7
  7. Yousefiasl S8
  8. Sharma S1
  9. Maleki A9, 10, 11
  10. Rabiee N12, 13
  11. Kumar AP14, 15
  12. Thakur VK16, 17, 18
  13. Orive G19, 20, 21
  14. Sharifi E22, 23
  15. Kumar A1
  16. Makvandi P24

Source: Seminars in Cancer Biology Published:2022


Abstract

Chemotherapy is the first choice in the treatment of cancer and is always preferred to other approaches such as radiation and surgery, but it has never met the need of patients for a safe and effective drug. Therefore, new advances in cancer treatment are now needed to reduce the side effects and burdens associated with chemotherapy for cancer patients. Targeted treatment using nanotechnology are now being actively explored as they could effectively deliver therapeutic agents to tumor cells without affecting normal cells. Dendrimers are promising nanocarriers with distinct physiochemical properties that have received considerable attention in cancer therapy studies, which is partly due to the numerous functional groups on their surface. In this review, we discuss the progress of different types of dendrimers as delivery systems in cancer therapy, focusing on the challenges, opportunities, and functionalities of the polymeric molecules. The paper also reviews the various role of dendrimers in their entry into cells via endocytosis, as well as the molecular and inflammatory pathways in cancer. In addition, various dendrimers-based drug delivery (e.g., pH-responsive, enzyme-responsive, redox-responsive, thermo-responsive, etc.) and lipid-, amino acid-, polymer- and nanoparticle-based modifications for gene delivery, as well as co-delivery of drugs and genes in cancer therapy with dendrimers, are presented. Finally, biosafety concerns and issues hindering the transition of dendrimers from research to the clinic are discussed to shed light on their clinical applications. © 2022 Elsevier Ltd
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