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Dendrimers As Nanoscale Vectors: Unlocking the Bars of Cancer Therapy Publisher Pubmed



Dey AD1 ; Bigham A2 ; Esmaeili Y3 ; Ashrafizadeh M4, 5 ; Moghaddam FD6 ; Tan SC7 ; Yousefiasl S8 ; Sharma S1 ; Maleki A9, 10, 11 ; Rabiee N12, 13 ; Kumar AP14, 15 ; Thakur VK16, 17, 18 ; Orive G19, 20, 21 ; Sharifi E22, 23 Show All Authors
Authors
  1. Dey AD1
  2. Bigham A2
  3. Esmaeili Y3
  4. Ashrafizadeh M4, 5
  5. Moghaddam FD6
  6. Tan SC7
  7. Yousefiasl S8
  8. Sharma S1
  9. Maleki A9, 10, 11
  10. Rabiee N12, 13
  11. Kumar AP14, 15
  12. Thakur VK16, 17, 18
  13. Orive G19, 20, 21
  14. Sharifi E22, 23
  15. Kumar A1
  16. Makvandi P24
Show Affiliations
Authors Affiliations
  1. 1. Chitkara College of Pharmacy, Chitkara University, Punjab, India
  2. 2. Institute of Polymers, Composites and Biomaterials—National Research Council (IPCB-CNR), Viale J.F. Kennedy 54—Mostra d′Oltremare pad. 20, Naples, 80125, Italy
  3. 3. Biosensor Research Center (BRC), School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Faculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Universite Caddesi No. 27, Orhanli, Tuzla, Istanbul, 34956, Turkey
  5. 5. Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, Istanbul, 34956, Turkey
  6. 6. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, 1477893855, Iran
  7. 7. UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  8. 8. School of Dentistry, Hamadan University of Medical Sciences, Hamadan, 6517838736, Iran
  9. 9. Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, 45139-56184, Iran
  10. 10. Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University of Medical Sciences, Zanjan, 45139-56184, Iran
  11. 11. Cancer Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, 1989934148, Iran
  12. 12. Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Gyeongbuk, Pohang, 37673, South Korea
  13. 13. School of Engineering, Macquarie University, Sydney, 2109, NSW, Australia
  14. 14. Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore
  15. 15. NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119077, Singapore
  16. 16. Biorefining and Advanced Materials Research Center, Scotland's Rural College (SRUC), Kings Buildings, Edinburgh, EH9 3JG, United Kingdom
  17. 17. School of Engineering, University of Petroleum & Energy Studies (UPES), Uttarakhand, Dehradun, 248007, India
  18. 18. Centre for Research & Development, Chandigarh University, Punjab, Mohali, 140413, India
  19. 19. NanoBioCel Research Group, School of Pharmacy, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, Spain
  20. 20. University Institute for Regenerative Medicine and Oral Implantology - UIRMI (UPV/EHU-Fundacion Eduardo Anitua), Vitoria-Gasteiz, Spain
  21. 21. Bioaraba, NanoBioCel Research Group, Vitoria-Gasteiz, Spain
  22. 22. Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran
  23. 23. Institute of Polymers, Composites and Biomaterials, National Research Council (IPCB-CNR), Naples, 80125, Italy
  24. 24. Istituto Italiano di Tecnologia, Centre for Materials Interfaces, Pisa, Pontedera, 56025, Italy

Source: Seminars in Cancer Biology Published:2022


Abstract

Chemotherapy is the first choice in the treatment of cancer and is always preferred to other approaches such as radiation and surgery, but it has never met the need of patients for a safe and effective drug. Therefore, new advances in cancer treatment are now needed to reduce the side effects and burdens associated with chemotherapy for cancer patients. Targeted treatment using nanotechnology are now being actively explored as they could effectively deliver therapeutic agents to tumor cells without affecting normal cells. Dendrimers are promising nanocarriers with distinct physiochemical properties that have received considerable attention in cancer therapy studies, which is partly due to the numerous functional groups on their surface. In this review, we discuss the progress of different types of dendrimers as delivery systems in cancer therapy, focusing on the challenges, opportunities, and functionalities of the polymeric molecules. The paper also reviews the various role of dendrimers in their entry into cells via endocytosis, as well as the molecular and inflammatory pathways in cancer. In addition, various dendrimers-based drug delivery (e.g., pH-responsive, enzyme-responsive, redox-responsive, thermo-responsive, etc.) and lipid-, amino acid-, polymer- and nanoparticle-based modifications for gene delivery, as well as co-delivery of drugs and genes in cancer therapy with dendrimers, are presented. Finally, biosafety concerns and issues hindering the transition of dendrimers from research to the clinic are discussed to shed light on their clinical applications. © 2022 Elsevier Ltd
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