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Association Between Interleukin-23 Receptor R381q Gene Polymorphism and Asthma Pubmed



Mosayebian A1 ; Hakemi MG2 ; Meshkat R3 ; Ghasemi R1 ; Ahmad HK4 ; Samadi M5, 6
Authors
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Authors Affiliations
  1. 1. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Cellular and Molecular Immunology Research Center, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Immunology, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
  4. 4. Department of Genetics and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  6. 6. Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Source: Iranian Journal of Allergy, Asthma and Immunology Published:2015


Abstract

The SNP (rs11209026, Arg381Gln, R381Q) in the IL-23 receptor (IL23R) confers protection against multiple inflammatory diseases, representing one of the most significant human genetic polymorphisms in inflammatory diseases. We, therefore, investigated the association between IL-23 R R381Q gene polymorphism and asthma. This case-control study was performed on 209 patients, and 200 healthy controls. Using PCR-RFLP, the R381Q variant was screened in the IL-23R gene of the patients and controls. Serum IgE levels were measured using ELISA technique. Eosinophil absolute count was done with Sesmex cell counter. Our results indicated that the genotype and allele frequencies of the IL-23R R381Q polymorphism is significantly different between asthmatic patients and control subjects (p<0.001; odd ratio= 0.266; 95%, CI=0.118-0.604. Moreover, the asthmatic patients had higher eosinophil count and total serum IgE levels than controls as expected (p<0.001). The present study suggested that R381Q polymorphism in IL-23 receptor may be a predisposing allele for asthma. Copyright© Summer 2015, Iran J Allergy Asthma Immunol. All rights reserved.
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