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Association of Interleukin-4 Receptor Α Chain I50v Gene Variant (Rs1805010) and Asthma in Iranian Population: A Case-Control Study Publisher



Mowahedi M1 ; Aramesh A2 ; Khouzani MS3 ; Khouzani MS3 ; Daryanoush S2 ; Samet M4 ; Samadi M5
Authors
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Authors Affiliations
  1. 1. Abortion Research Center, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  2. 2. Thalassemia and Hemophilia Research Center, Shahid Dastgheib Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Cellular and Molecular Biology-Genetic Center, Falavarjan Azad University, Isfahan, Iran
  4. 4. Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  5. 5. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Open Respiratory Medicine Journal Published:2024


Abstract

Background: Asthma is one of the respiratory disorders caused by chronic airway inflammation. IL-4 has been identified as one of the participating interleukins in the severity of asthma. Objective: A case-control study was conducted to determine the association of rs1805010, a single nucleotide polymorphism in the interleukin 4 receptor α chain, with asthma and immunoglobulin E and IL-17A serum levels in Iranian populations. Methods: ELISA was used to investigate the relationship between three different varieties of SNP I50V and serum IL-17A levels, as well as total IgE levels. Based on GINA criteria, patients were classified into mild, moderate, and severe groups based on the association between SNP I50V, IL-17A, and total IgE. In order to analyze the data, the student-t-test and the one-way ANOVA were used. Results: The SNP I50V was associated with asthma in a significant way (p = 0.001). IL-17A and total IgE levels were significantly higher in asthmatic patients than in control participants (p 0.05 and p 0.021, respectively), but neither showed any association with SNP I50V in the asthmatic patients. Conclusion: Asthma patients have a higher prevalence of the I allele, reflecting the significance of Th2 cells. Although total IgE and IL-17A levels increased in both disease subgroups, total IgE level augmentation correlates directly with disease severity, while IL-17A level enhancement does not. © 2024 The Author(s). Published by Bentham Open.
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