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Chromium-Induced Hyperglycemia in the Rat Publisher Pubmed



Ghafghazi T1 ; Maghbareh A1 ; Barnett R1
Authors

Source: Toxicology Published:1979


Abstract

The acute administration of chromium chloride (Cr) produces hyperglycemia in rats. Adrenalectomy prevents the hyperglycemic effect but not the glucose intolerance. Subacute exposure of rats to Cr for 7-23 days does not change the testing glucose nor is there an acute or subacute effect on tolerance to glucose load. Administration of Cr does not influence acute insulin hypoglycemia. Thus contrary to Cr deficient animal, at the concentrations tested, Cr appears to be a hyperglycemic agent to rats with minimal subacute effects. © 1979.