The Relationship of High-Sensitivity C-Reactive Protein (Hs-Crp) Serum Level and Peritonitis in Patients on Peritoneal Dialysis

Summary: 1-year study of 89 dialysis patients ties rising inflammation to higher infection odds, lower protein in cases. Tracking could prevent issues—key for kidney care. #KidneyCare #DialysisHealth

Mortazavi M¹ ; Najafi M² ; Najafi R³ ; Seirafian S¹ ; Karimi S¹ ; Hosseini SM⁴
Source: Journal of Isfahan Medical School Published:2017

Abstract

Background: C-reactive protein (CRP) is a predictor of cardiovascular diseases in both normal people and patients on hemodialysis. This study aimed to assess the relationship of high-sensitivity C-reactive protein (Hs-CRP) serum level and peritonitis in patients on peritoneal dialysis. Methods: 113 patients on peritoneal dialysis in Isfahan city, Iran, participated in our study in 2015. Serum albumin and Hs-CRP levels were measured in each patient at three times (baseline, and 6 and 12 month after that) and the patients were followed up for 1 year. All the patients were evaluated for peritonitis in every visit. At the end of the study, two groups of patients on peritoneal dialysis with and without peritonitis were compared. Findings: Among 113 patients, 24 were excluded from the study because of death or kidney transplantation and 89 patients were included in final analysis. The mean Hs-CRP levels in patients with peritonitis were 4.83, 5.79, and 7.42 mg/l at baseline, and 6 and 12 month after it, respectively; these levels were 4.47, 3.19, and 2.69 mg/l in patients without peritonitis, respectively. In addition, the mean albumin levels in patient with peritonitis were 3.38, 3.29 and 3.40 mg/l at baseline, and 6 and 12 month after it, respectively; these values were 3.56, 4.05, and 3.51 mg/l in patients without peritonitis, respectively. Conclusion: Results showed that with increase in Hs-CRP level, the risk of peritonitis increased. Besides, the albumin level decreased among patients with peritonitis in comparison with patients without peritonitis; there was no significant correlation between albumin level and peritonitis. © 2017, Isfahan University of Medical Sciences(IUMS). All rights reserved.