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Vulvovaginal Candidiasis: An Overview of Mycological, Clinical, and Immunological Aspects Publisher Pubmed



Jafarzadeh L1 ; Ranjbar M2 ; Nazari T3 ; Naeimi Eshkaleti M4, 5 ; Aghaei Gharehbolagh S4 ; Sobel JD6 ; Mahmoudi S7
Authors
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Authors Affiliations
  1. 1. Department of Immunology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
  2. 2. Department of Persian Medicine, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Medical Geriatrics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI, United States
  7. 7. Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Journal of Obstetrics and Gynaecology Research Published:2022


Abstract

Aim: To provide an overview of clinical, immunological, and mycological aspects of vulvovaginal candidiasis (VVC). Methods: A literature search was conducted to find relevant articles about different aspects of VVC. Related data from retrieved articles were summarized in different headings. Results: VVC has a global distribution and Candida albicans is the leading cause of infection except for specific patient groups like postmenopausal, diabetic, or immunocompromised women. VVC has a range of clinical presentations, accordingly, its diagnosis should be based on clinical examination coupled with laboratory investigations. The best therapeutic regimen depends on the patient's conditions and the causative agent. Moreover, factors like drug resistance of the causative agents and different mutations in the immunity-related genes could affect the treatment outcome. Conclusion: As a globally distributed disease, VVC needs further attention, especially in areas related to the treatment failure and recurrence of the disease. © 2022 Japan Society of Obstetrics and Gynecology.
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