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Antifungal Effect of Echinophora Platyloba Essence Against the Candida Species Isolated From Vulvovaginal Candidiasis, Compared With Fluconazole



Aminian N1, 2, 3 ; Dehghan P1, 2, 3 ; Chadeganipour M1, 2, 3 ; Sajadi E4 ; Yazdi M5
Authors
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Authors Affiliations
  1. 1. Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Pharmacognosy, School of Pharmacology, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2014

Abstract

Background: Candidiasis is one of the most important opportunistic human infections. These infections have been increased due to overuse of antifungal drugs, especially fluconazole. The species has shown a relative resistance to fluconazole which is the first choice of vulvovaginal candidiasis treatment. Herbals are traditional source for medicinal drugs. Study on Echinophora platyloba, a domestic Iranian medicinal plant, could be helpful to find the alternative therapeutic agent for the cure of resistant infections. Methods: Clinical strains isolated from vaginal candidiasis which was identified via the method of Auxanogram with RapID™ yeast plus system. Well-diffusion assay was used to determine the susceptibility of both fluconazole and essence of Echinophora platyloba on Candida species. For obtaining minimal inhibitory concentration of 50% (MIC50) and 90% (MIC90) and minimal fungicidal concentration (MFC), different dilutions were examined and compared on different species using microdilution of fluconzole and essence. The results were evaluated according to NCCLS (National Committee for Clinical Laboratory Standards) method. Findings: From a total of 15 isolates, 10 (66%) were sensitive to fluconazole but 3 (14%) isolates, Candida gabrata, Candida krusei and Candida rogusa, showed resistance to this drug; meanwhile, they were dose-dependent to the essence of Echinophora platyloba. One isolate (6%) was sensitive to essence of Echinophora platyloba, whereas 7 isolates (47%) were dose-dependent and 7 (47%) were resistant to this essence. MIC50, MIC90, MFC for fluconazole and essence was observed in isolate No. 31 (Candida albicans) and maximum concentration of them was related to No. 68 (Candida krusei). Conclusion: Using the essence of Echinophora platyloba along with the fluconazole would help to treat the resistant forms of candidiasis. © 2014, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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