New 3-Hydroxypyridine-4-One Analogues: Their Synthesis, Antimicrobial Evaluation, Molecular Docking, and in Silico Adme Prediction

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New 3-Hydroxypyridine-4-One Analogues: Their Synthesis, Antimicrobial Evaluation, Molecular Docking, and in Silico Adme Prediction Publisher Pubmed

Sadeghian S¹ ; Zare F^{1, 2} ; Saghaie L³ ; Fassihi A³ ; Zare P^{4, 5} ; Sabet R¹

Source: Medicinal Chemistry Published:2024

Abstract

Introduction: Drug resistance to existing antimicrobial drugs has become a serious threat to human health, which highlights the need to develop new antimicrobial agents. Methods: In this study, a new set of 3-hydroxypyridine-4-one derivatives (6a-j) was synthesized, and the antimicrobial effects of these derivatives were evaluated against a variety of microorganisms using the microdilution method. The antimicrobial evaluation indicated that compound 6c, with an electron-donating group -OCH3 at the meta position of the phenyl ring, was the most active compound against S. aureus and E. coli species with an MIC value of 32 μg/mL. Compound 6c was more potent than ampicillin as a reference drug. Results: The in vitro antifungal results showed that the studied derivatives had moderate effects (MIC = 128-512 μg/mL) against C. albicans and A. niger species. The molecular modeling studies revealed the possible mechanism and suitable interactions of these derivatives with the target protein. Conclusion: The obtained biological results offer valuable insights into the design of more effective antimicrobial agents. © 2024 Bentham Science Publishers. All Rights Reserved.

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Style	Citing Format
MLA	Sadeghian S, et al.. "New 3-Hydroxypyridine-4-One Analogues: Their Synthesis, Antimicrobial Evaluation, Molecular Docking, and in Silico Adme Prediction." Medicinal Chemistry, vol. 20, no. 9, 2024, pp. 900-911.
APA	Sadeghian S, Zare F, Saghaie L, Fassihi A, Zare P, Sabet R (2024). New 3-Hydroxypyridine-4-One Analogues: Their Synthesis, Antimicrobial Evaluation, Molecular Docking, and in Silico Adme Prediction. Medicinal Chemistry, 20(9), 900-911.
Chicago	Sadeghian S, Zare F, Saghaie L, Fassihi A, Zare P, Sabet R. "New 3-Hydroxypyridine-4-One Analogues: Their Synthesis, Antimicrobial Evaluation, Molecular Docking, and in Silico Adme Prediction." Medicinal Chemistry 20, no. 9 (2024): 900-911.
Harvard	Sadeghian S et al. (2024) 'New 3-Hydroxypyridine-4-One Analogues: Their Synthesis, Antimicrobial Evaluation, Molecular Docking, and in Silico Adme Prediction', Medicinal Chemistry, 20(9), pp. 900-911.
Vancouver	Sadeghian S, Zare F, Saghaie L, Fassihi A, Zare P, Sabet R. New 3-Hydroxypyridine-4-One Analogues: Their Synthesis, Antimicrobial Evaluation, Molecular Docking, and in Silico Adme Prediction. Medicinal Chemistry. 2024;20(9):900-911.
BibTex	@article{ author = {Sadeghian S and Zare F and Saghaie L and Fassihi A and Zare P and Sabet R}, title = {New 3-Hydroxypyridine-4-One Analogues: Their Synthesis, Antimicrobial Evaluation, Molecular Docking, and in Silico Adme Prediction}, journal = {Medicinal Chemistry}, volume = {20}, number = {9}, pages = {900-911}, year = {2024} }
RIS	TY - JOUR AU - Sadeghian S AU - Zare F AU - Saghaie L AU - Fassihi A AU - Zare P AU - Sabet R TI - New 3-Hydroxypyridine-4-One Analogues: Their Synthesis, Antimicrobial Evaluation, Molecular Docking, and in Silico Adme Prediction JO - Medicinal Chemistry VL - 20 IS - 9 SP - 900 EP - 911 PY - 2024 ER -

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