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Comparison of Bone Mineral Density in Isfahani Women With Other Populations: The Impact on Diagnosis of Using Different Normal Ranges Publisher



Salamat MR1 ; Tavakoli MB1 ; Salehi M2 ; Pishva E3 ; Salari AH4 ; Tabesh F5
Authors
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Authors Affiliations
  1. 1. Department of Medical Physics, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Microbiology, Isfahan University of Medical Sciences, Tehran, Iran
  4. 4. Unit of Rheumatology Research, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Asian Journal of Scientific Research Published:2009


Abstract

Bone Mineral Density (BMD) of 359 healthy Isfahani women aged 23-60 years were compared with the Caucasian's, Tehranis and some Arab women. BMD was determined using dual energy X-ray absorptiometry (DXA) at the lumbar spine and proximal femur. Age related changes in BMD were similar to those described in Lebanese and Saudis for the femur, Lebanese having the lowest femur BMD. However, the age related values for the spine were similar for all populations, having the lowest BMD values for the Isfahani women. The problem of using manufacture provided reference data was investigated. In fact using the manufacture provided reference data for the femoral neck diagnosed only 14.9% of the postmenopausal women as normal due to improper use of T-score, while using the Isfahan normative data 41.9% of the postmenopausal women were diagnosed as normal. The normative peak BMD values acquired for Iranian women in Isfahan and Tehian were different, in particular for the spine. The normative BMD values in Isfahan were only acquired for the young women. Therefore, for the management of patients, determining the secondary causes of osteoporosis (Z-scores<-2) it is highly recommended to establish the normal range for the entire age range of 20-80 years normal women and make further investigations to find the reason(s) for the discrepancies in the normal BMD ranges of women in Iran. © 2009 Asian Network for Scientific Information.
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