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Comparison of the Prevalence of Osteopenia and Osteoporosis in Postmenopausal Women With and Without Type 2 Diabetes Mellitus



Aghajanpoor M1 ; Salari A2 ; Karimifar M3, 5 ; Zamani A4 ; Salesi M3, 5 ; Mottaghi P3, 5
Authors
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Authors Affiliations
  1. 1. Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Rheumatology, School of Medicine, Baghiyatallah University of Medical Sciences, Tehran, Iran
  3. 3. Department of Rheumatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Community Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Rheumatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2014

Abstract

Background: Osteoporosis and diabetes mellitus are major and growing public health problems, particularly among postmenopausal women. This study was conducted to evaluate the relationship between osteoporosis and type 2 diabetes mellitus (DM) in postmenopausal women. Methods: In this cross sectional study, we compared 200 postmenopausal women with type 2 diabetes mellitus and 400 without it, over the age of 60 years. Age, body mass index (BMI), and the T-score of the lumbar vertebra, neck of femur measured via Dual Energy X-ray Absorptiometry (DEXA) were recorded and compared between the two groups. Hemoglobin A1C (HbA1C) was also measured in patients with type 2 diabetes mellitus and its correlation with osteoporosis was studied. Chi-square, Fisher’s exact and independent t tests were used for analyzing the data. In this study, P-value less than 0.05 was considered as significant. Findings: The mean ages were 65.23 ± 4.80 vs. 66.91 ± 5.78 years and BMI were 28.94 ± 4.06 vs. 31.65 ± 4.42 kg/m2 in non-diabetic and diabetic groups, respectively. Lumber T-scores was -2.10 ± 1.08 vs. -2.16 ± 1.27 (P = 0.60), femoral neck T-score was -0.72 ± 1.00 vs. -1.09 ± 0.96 (P < 0.01), in non-diabetic and diabetic groups, respectively. The prevalence of osteopenia and osteoporosis was statistically higher among diabetic group compared to non-diabetics. In diabetic group, osteoporosis was more common in those with HbA1C ≥ 7 compared to those with HbA1C < 7 (P = 0.006). Conclusion: The results of this study showed that bone loss is more common in postmenopausal women ith type 2 diabetes mellitus compared to the postmenopausal women without it. We can control this risk factor, as an important intervention, in the prevention of osteoporosis. © 2014, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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