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Does L-Carnitine Improve Endothelial Function in Hemodialysis Patients?



Sabri MR1 ; Fahimi F2 ; Hajialiasgar S2 ; Etminan A3 ; Nazemi S2 ; Salehi F4
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Authors Affiliations
  1. 1. Child Growth and Development Research Center, Department of Pediatric Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Radiology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  3. 3. Department of Nephrology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  4. 4. Dialysis Ward, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran

Source: Journal of Research in Medical Sciences Published:2012

Abstract

Background: Atherosclerosis is the leading cause of death in hemodialysis patients. These patients are also very prone to Lcarnitine deficiency due to kidney disease. In this clinical trial, we investigated the effect of oral L-carnitine on endothelial function of these patients. Materials ans Methods: We studied 31 adult chronic hemodialysis patients in our center and divided them into two groups. The first group (n = 20) received 1500 mg/dialysis interval (every other day) oral L-carnitine. The control group (n = 11) received placebo for one month. Ultrasonographic measurements of flow mediated dilation and carotid intima-media thickness were performed before and after one month of L-carnitine and placebo therapy. Results: This study showed that after one month of Lcarnitine or placebo therapy there was no significant improvement in flow mediated dilation (p = 0.80 and p = 0.59, respectively) or decrease in carotid intima-media thickness (p = 0.12 and p = 0.50, respectively). Conclusions: Our study revealed that one month of oral L-carnitine therapy did not improve endothelial function in hemodialysis patients. Long-term studies with large sample size using intravenous form and higher doses of the drug are required to clarify the questionable role of L-carnitine in hemodialysis patients.
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