Bovine Colostrum in Increased Intestinal Permeability in Healthy Athletes and Patients: A Meta-Analysis of Randomized Clinical Trials Publisher Pubmed



Hajihashemi P¹ ; Haghighatdoost F² ; Kassaian N³ ; Hoveida L⁴ ; Tamizifar B¹ ; Nili H⁵ ; Rahim Khorasani M⁶ ; Adibi P¹ Show Affiliations
Source: Digestive Diseases and Sciences Published:2024

Abstract

Background: Increasing intestinal permeability causes chronic inflammation, which is one of the etiological factors of many diseases that presently constitute global challenges. Aims: Considering the importance of developing therapies to eliminate the increased intestinal permeability, in this systematic review and meta-analysis, we analyze the impact of bovine colostrum (BC) on the gut barrier and its permeability. Methods: Online databases, including PubMed, ISI Web of Science, and Scopus, were searched to find pertinent articles up to March 2022. Weighted mean difference (WMD) and 95% confidence intervals (CI) were considered as effect sizes. The random-effects model was used to pool the study results. Results: A total of ten articles were included in the meta-analysis. The pooled effect revealed a significant reduction in the 5-h urinary lactulose/rhamnose ratio after BC consumption [mean difference (MD): −0.24; 95% CI −0.43 to −0.04; I2 = 99%] and urinary lactulose/mannitol ratio (MD: −0.01; 95% CI −0.02 to −0.001; I2 = 29.8%). No differences were observed in the plasma intestinal fatty acid-binding protein (I-FABP) between BC and control groups (MD: 2.30; 95% CI −293.9 to 298.5; I2 = 92%). Conclusions: BC supplementation significantly reduced intestinal permeability; however, to confirm the results, more randomized clinical trials considering different quality, dose, and duration are needed. Graphical Abstract: (Figure presented.). © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. corrected publication 2024.