Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Therapeutics Effects of Bovine Colostrum Applications on Gastrointestinal Diseases: A Systematic Review Publisher Pubmed



Hajihashemi P1 ; Haghighatdoost F2 ; Kassaian N3 ; Rahim Khorasani M4 ; Hoveida L5 ; Nili H6 ; Tamizifar B1 ; Adibi P1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Isfahan Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran
  5. 5. Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
  6. 6. Zeitoon Isfahan Vaccine Innovators Company, Isfahan Scince and Technology Town, Isfahan, Iran

Source: Systematic Reviews Published:2024


Abstract

Background: Evidence on the effects of bovine colostrum (BC) supplementation on gastrointestinal (GI) diseases is conflicting. Objectives: This systematic review summarized the findings of clinical trials (CTs) on the effects of BC supplementation on GI diseases. Methods: A systematic search was conducted in online databases, including PubMed, ISI Web of Science, and Scopus, until March 2021 and updated until December 2023. CTs investigated BC’s effect on any measurable symptomatic change in terms of GI health as the primary outcome variable or as one of the outcomes in any population eligible for this systematic review. Results: Out of 6881 records, 22 CTs (uncontrolled = 4, cross-over = 1, and parallel = 17) with 1427 patients were enrolled in the systematic review. Diarrhea, the most frequently evaluated symptom (20 interventional arms), was decreased in frequency with BC supplementation in 15 of these arms. However, most studies reported no change in its duration. BC supplementation consistently reduced stool frequency across all seven studies. Abdominal pain relief was noted in four interventional arms but showed no improvement in five others. Assessment of other GI symptoms was limited, yielding inconclusive results. Conclusions: There is limited evidence on the effects of BC on GI diseases, with mixed findings. More well-designed controlled clinical trials are required to explore its effects. © The Author(s) 2024.
Related Docs
View other Related Docs
1. Bovine Colostrum in Increased Intestinal Permeability in Healthy Athletes and Patients: A Meta-Analysis of Randomized Clinical Trials, Digestive Diseases and Sciences (2024)
2. Association of Dairy Consumption and Irritable Bowel Syndrome in Iranian Adults, Journal of Isfahan Medical School (2016)
3. Is Dairy Foods Restriction Mandatory for Inflammatory Bowel Disease Patients: A Multinational Cross-Sectional Study; [Restricao De Alimentos Lacteos E Obrigatoria Para Pacientes Com Doenca Inflamatoria Intestinal? Estudo Transversal Multinacio-Nal. Arq Gastroenterol.], Arquivos de Gastroenterologia (2022)
4. The Effectiveness of Synbiotics in Preventing Antibiotic-Associated Diarrhea in Children: A Double-Blind Randomized Clinical Trial, Archives of Pediatric Infectious Diseases (2019)
5. Comparison and Assessment of Flixweed and Fig Effects on Irritable Bowel Syndrome With Predominant Constipation: A Single-Blind Randomized Clinical Trial, Explore (2019)
6. Impact of Probiotics on Gastrointestinal Function and Metabolic Status After Roux-En-Y Gastric Bypass: A Double-Blind, Randomized Trial, Obesity Surgery (2024)
7. Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-Analyses of Randomized Clinical Trials, Nutrition Reviews (2025)
8. Dairy Intolerance Syndrome in Iranian Young Adult, Journal of Research in Medical Sciences (2009)
Experts (# of related papers)
View all Related Experts
Peyman Adibi (6)
Atefeh Sadeghizadeh (1)
Other Related Docs
9. Effects of Soy Milk Consumption on Gut Microbiota, Inflammatory Markers, and Disease Severity in Patients With Ulcerative Colitis: A Study Protocol for a Randomized Clinical Trial, Trials (2020)
10. The Effects of Probiotic Supplementation on Functional Constipation Following Colonoscopy: A Double-Blinded Randomized Controlled Trial, Current Nutrition and Food Science (2025)
11. Efficacy and Safety of Saccharomyces Boulardii for Acute Diarrhea, Pediatrics (2014)
12. The Efficacy of a Synbiotic Containing Bacillus Coagulans in Treatment of Irritable Bowel Syndrome: A Randomized Placebo-Controlled Trial, Gastroenterology and Hepatology from Bed to Bench (2014)
13. The Effect of Probiotic and Synbiotic Consumption on the Most Prev-Alent Chemotherapy-Related Complications: A Systematic Review of Current Literature, Current Medicinal Chemistry (2022)