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Angiotensinogen-M235t As a Risk Factor for Myocardial Infarction in Asian Populations: A Genetic Association Study and a Bioinformatics Approach Publisher Pubmed



Raygan F1 ; Karimian M2, 3 ; Rezaeian A3 ; Bahmani B4 ; Behjati M5
Authors
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Authors Affiliations
  1. 1. Department of Cardiology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Gametogenesis Research Center, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran
  4. 4. Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran
  5. 5. Cardiovascular research center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Croatian Medical Journal Published:2016


Abstract

Aim To investigate if there is an association between M235T polymorphism of angiotensinogen gene and myocardial infarction (MI) risk and perform a meta-analysis and an in silico approach. Methods This case-control study included 340 participants (155 MI patients and 185 controls) examined at Kashan University of Medical Sciences (Kashan, Iran) between 2013 and 2015. Meta-analysis included 25 studies with 6334 MI patients and 6711 controls. Bioinformatics tools were applied to evaluate the impact of M235T polymorphism on angiotensinogen function and structure. Results Genetic association study revealed a significant association between TT genotype (odds ratio [OR] 2.08, 95% confidence interval [CI] 1.08-4.00, P = 0.029) and T allele (OR 1.45, 95% CI 1.06-1.99, P = 0.021) and MI risk. Meta-analysis also revealed a significant association between M235T polymorphism and MI risk in allelic (OR 1.55, 95% CI 1.10- 2.18, P = 0.012) and recessive (OR 1.69, 95% CI 1.13-2.53, P = 0.010) models within Asian population. In silico-analysis revealed that M235T fundamentally changed the function of angiotensinogen (score 32; expected accuracy 66%). Conclusions Our study suggests that M235T polymorphism might be a helpful biomarker for screening of susceptible individuals for MI in Asian population.
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