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Joint Effects of Dietary Patterns and Paraoxonase1 Rs662 Polymorphism on Coronary Artery Disease Severity (Gensini and Syntax Scores) and Its Risk Factors in Adults Undergoing Angiography Publisher Pubmed



Darand M1 ; Askari G2, 3 ; Feizi A4 ; Seyedhossaini S5 ; Ashrafzadeh H6 ; Arabi V7, 8 ; Yavari M9 ; Vasmehjani AA8, 10 ; Salehiabargouei A5, 7, 8
Authors
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Authors Affiliations
  1. 1. Prevention of Cardiovascular Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Community Nutrition, School of Nutrition & Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Biostatistics and Epidemiology, School of Health, and Clinical Toxicology Research Center and Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Yazd Cardiovascular Research Center, Noncommunicable Disease Research Institute, Shahid Sadoughi University of Medical Science, Yazd, Iran
  6. 6. Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  7. 7. Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  8. 8. Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  9. 9. Division of Genetics, Department of Cell and Molecular Biology and Microbiology, Faculty of Science and Biotechnology, University of Isfahan, Isfahan, Iran
  10. 10. Nutrition Improvement Group
  11. 11. Health Department, Guilan University of Medical Sciences, Guilan, Iran

Source: Molecular Nutrition and Food Research Published:2024


Abstract

Scope: The present study aims to assess the interaction of dietary patterns (DPs) and paraoxonase1 (PON1) rs662 polymorphism on coronary artery disease (CAD) severity and its risk factors. Methods and results: This cross-sectional study is conducted on 425 patients undergoing angiography. The PON1 genotypes are detected by the polymerase chain reaction-restriction fragment length polymorphism (RFLP-PCR) technique. DPs are extracted by exploratory factor analysis. Two dietary patterns Western (WDP) and Traditional (TDP) are extracted. A gene-diet interaction concerning a high Gensini score is observed. Accordingly, high adherence to the WDP increases the odds of a high Gensini score in R allele carriers compared to QQ genotype carriers by 2.48 times (odds ratio [OR]: 2.48, 95% confidence interval [CI] 0.98–6.26, p = 0.05). Also, the risk of high systolic blood pressure (SBP) is higher in R allele carriers with high adherence to the WDP compared to QQ genotype carriers (OR: 3.49, 95% CI 1.38–8.82, p < 0.001. No significant interaction is observed between TDP and PON1 rs662 on any cardiometabolic risk factors (p-value > 0.05). The results remain significant after adjusting for confounders. Conclusion: The present study's findings indicate the existence of an interaction between the PON1 rs662 polymorphism and the WDP on the risk of stenosis severity and high SBP. © 2024 Wiley-VCH GmbH.
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