Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Correlation of Caga Positive Helicobacter Pylori Infection With Clinical Outcomes in Alzahra Hospital, Isfahan, Iran



Safaei HG1 ; Tavakkoli H2 ; Mojtahedi A3 ; Salehei R4 ; Soleimani B5 ; Pishva E1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Microbiology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Gastroenterology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Microbiology, Guilan University of Medical Sciences, Guilan, Iran
  4. 4. Department of Molecular Biology, IUMS, Isfahan, Iran
  5. 5. School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Research in Medical Sciences Published:2008

Abstract

Background: Helicobacter pylori causes chronic active gastritis, peptic ulcer, non-cardia gastric cancer and mucosal-associated lymphoid tissue (MALT) lymphoma. Different genotypes of Helicobacter pylori are confirmed from disease geographical areas. Its association with clinical disease remained controversial. The aim of the present study was to investigate the relationship of the cagA genotype of Helicobacter pylori isolates with clinical manifestations and its relation to age and sex of patients. Methods: A total of 100 patients (60 male and 40 female) biopsy specimens were obtained from 3 groups of patients (40 chronic active gastritis, 40 duodenal ulcers and 20 non-gastric gastric cancers). Biopsies were cultured on specific medium and after growth colonies were confirmed as Helicobacter pylori. DNA extraction and polymerase chain reaction (PCR) were used to detect the presence or absence of cagA gene. Results: From a total of 100 positive samples of H. pylori, cagA genes were detected in 68% of patients and 32% of samples were negative. Mean age of normal gastritis, duodenal ulcer and gastric adenocarcinoma was 44.94, 44.97 and 67.5 years, respectively. Conclusions: The present study showed no significant relationship between cagA genotype of H. pylori and chronic active gastritis, duodenal ulcer and non-cardia gastric cancer as well as sex of patients. But, in gastric adenocarcinoma, there was significant discrepancy between ages of patients in comparison with the other two groups.
Related Docs
View other Related Docs
1. Helicobacter Pylori in Iran: A Systematic Review on the Association of Genotypes and Gastroduodenal Diseases, Journal of Research in Medical Sciences (2012)
2. Relation of Bab A2 Genotype of Helicobacter Pylori Infection With Chronic Active Gastritis, Duodenal Ulcer and Non-Cardia Active Gastritis in Alzahra Hospital Isfahan, Iran, Jundishapur Journal of Microbiology (2010)
3. Study of Vac a Genotypes of H.Pylori Isolated From Patients With the Upper Gastrointestinal Diseases by Pcr, Journal of Isfahan Medical School (2009)
4. Epiya Motif Genetic Characterization From Helicobacter Pylori Isolates in Distinct Geographical Regions of Iran, Advanced Biomedical Research (2022)
5. Frequency of Virulence Factors in Helicobacter Pylori-Infected Patients With Gastritis, Microbial Pathogenesis (2015)
6. Comparison of Four Invasive Methods for Diagnosis of Helicobacter Pylori Infection: Fluorescence in Situ Hybridization, Histology, Culture, Rapid Urease Test, Molecular Genetics, Microbiology and Virology (2020)
7. Correlation Between Mucosal Il-6 Mrna Expression Level and Virulence Factors of Helicobacter Pylori in Iranian Adult Patients With Chronic Gastritis, Jundishapur Journal of Microbiology (2015)
8. Molecular Assessment of Resistance to Clarithromycin in Helicobacter Pylori Strains Isolated From Patients With Dyspepsia by Fluorescent in Situ Hybridization in the Center of Iran, BioMed Research International (2020)
Experts (# of related papers)
View all Related Experts
Sharareh Moghim (8)
Mohammad Hossein Sanei (7)
Other Related Docs
9. Are Endoscopic Findings Predictive for the Presence of H. Pylori Infection? What About Indirect Histologic Findings?, Journal of Research in Medical Sciences (2007)
10. Associations of a Tlr4 Single-Nucleotide Polymorphism With H.Pylori Associated Gastric Diseases in Iranian Patients, Clinics and Research in Hepatology and Gastroenterology (2014)
11. Seroprevalence of Helicobacter Pylori Infection in Iranian Adolescents: The Caspian- Iii Study, International Journal of Pediatrics (2017)
12. Mucosal Interleukin-21 Mrna Expression Level Is High in Patients With Helicobacter Pylori and Is Associated With the Severity of Gastritis, Central European Journal of Immunology (2015)
13. Genetic Diversity of Helicobacter Pylori Isolates From Patients With Gastric Diseases in Isfahan, Advanced Biomedical Research (2022)
14. Epstein-Barr Virus/Helicobacter Pylori Coinfection and Gastric Cancer: The Possible Role of Viral Gene Expression and Shp1 Methylation, Iranian Journal of Microbiology (2022)
15. Evaluating Helicobacter Pylori Flaa in Clinical Isolates From Alzahra Hospital, Isfahan, Iran, Journal of Isfahan Medical School (2013)
16. The Correlation Between Atrophic Gastritis and Helicobacter Pylori Infection in Patients Referred to Shohadaye Ashayer Hospital in Khorramabad, Advancements in Life Sciences (2023)
17. Immunoblot Assay in Determination of Serum Antibody Profile of Helicobacter Pylori Infection, Iranian Journal of Medical Sciences (2003)
18. Virulence Factors of Helicobacter Pylori Vaca Increase Markedly Gastric Mucosal Tgf-Β1 Mrna Expression in Gastritis Patients, Microbial Pathogenesis (2014)
19. Comparison of the Sensitivity and Specificity of Available Methods in Helicobacter Pylori Infection Detection in Children, Journal of Isfahan Medical School (2013)
20. What Are the Effects of Il-1Β (Rs1143634), Il-17A Promoter (Rs2275913) and Tlr4 (Rs4986790) Gene Polymorphism on the Outcomes of Infection With H. Pylori Within As Iranian Population; a Systematic Review and Meta-Analysis, Gene Reports (2020)
21. Is Helicobacter Pylori Infection Prevalent in Middle East Countries?, Archives of Clinical Infectious Diseases (2022)
22. Helicobacter Pylori As a Zoonotic Infection: The Detection of H. Pylori Antigens in the Milk and Faeces of Cows, Journal of Research in Medical Sciences (2011)
23. Comparative Study on Cost and Effects of Non Invasive Helicobacter Pylori Diagnostic Tests, Journal of Isfahan Medical School (2011)
24. The Interaction of Helicobacter Pylori Infection and Type 2 Diabetes Mellitus, Advanced Biomedical Research (2019)
25. Comparison of Salivary Anti Helicobacter Pylori Igg With Serum Igg and Bacteriological Tests in Detecting Helicobacter Pylori Infections, Journal of Research in Medical Sciences (2005)
26. Stool Antigen Tests for the Detection of Helicobacter Pylori in Children, Iranian Journal of Pediatrics (2013)
27. Risk Factors for Helicobacter Pylori Infection and Its Relations With Iron Deficiency Anemia and Children's Growth, Journal of Isfahan Medical School (2013)
28. Association of Helicobacter Pylori Infection With Severity of Coronary Heart Disease, ARYA Atherosclerosis (2012)
29. Potential Transmission Sources of Helicobacter Pylori Infection: Detection of H. Pylori in Various Environmental Samples, Journal of Environmental Health Science and Engineering (2019)
30. Helicobacter Pylori's Evasion of the Immune System Could Establish an Inflammatory Environment That Potentially Induces the Development of Coronary Artery Disease, Jundishapur Journal of Microbiology (2013)
31. Production of Ifn-Γ and Il-4 Against Intact Catalase and Constructed Catalase Epitopes of Helicobacter Pylori From T-Cells, Jundishapur Journal of Microbiology (2015)
32. Is Helicobacter Pylori Infection a Risk Factor for Coronary Heart Disease?, ARYA Atherosclerosis (2012)
33. Detection of Helicobacter Pylori in City Water, Dental Units' Water, and Bottled Mineral Water in Isfahan, Iran, The Scientific World Journal (2013)
34. Diagnostic Values of Helicobacter Pylori Diagnostic Tests: Stool Antigen Test, Urea Breath Test, Rapid Urease Test, Serology and Histology, Journal of Research in Medical Sciences (2011)
35. Antibiotic Resistance Pattern of Helicobacter Pylori Strains Isolated From Patients in Isfahan, Iran, Journal of Research in Medical Sciences (2022)
36. Comparative Immune Response in Children and Adults With H. Pylori Infection, Journal of Immunology Research (2015)
37. Prevalence of Resistance of Helicobacter Pylori Strains to Selected Antibiotics in Isfahan, Iran, Jundishapur Journal of Microbiology (2013)
38. The Relation Between Microalbuminuria and Helicobacter Pylori Vaca Gene in Type 2 Diabetic Patients, Isfahan, Iran, Journal of Isfahan Medical School (2012)
39. Upregulation of Mir-222 in Both Helicobacter Pylori-Infected and Noninfected Gastric Cancer Patients, Journal of Genetics (2016)
40. Helicobacter Pylori Serum Antibody Titers in Patients With Cerebral Non-Cardioembolic Ischemic Stroke, Journal of Research in Medical Sciences (2011)
41. Mir-146A Is Deregulated in Gastric Cancer, Journal of Cancer Research and Therapeutics (2019)
42. Helicobacter Pylori in Iran: A Systematic Review on the Antibiotic Resistance, Iranian Journal of Basic Medical Sciences (2015)
43. Comparison of Helicobacter Pylori and Escherichia Coli in Induction of Tnf-Α Mrna From Human Peripheral Blood Mononuclear Cells, Indian Journal of Medical Microbiology (2010)
44. Resistance Pattern of Helicobacter Pylori Strains to Clarithromycin, Metronidazole, and Amoxicillin in Isfahan, Iran, Journal of Research in Medical Sciences (2013)
45. New Insight to Il-23/Il-17 Axis in Iranian Infected Adult Patients With Gastritis : Effects of Genes Polymorphisms on Expression of Cytokines, Acta Gastro-Enterologica Belgica (2015)
46. Evaluation of Various Water Resources in Isfahan, Iran, for the Presence of Helicobacter Pylori Using Fluorescent Nested Polymerase Chain Reaction, Journal of Isfahan Medical School (2014)
47. The Relation of Microalbuminuria and Helicobacter Pylori Caga Gene in Patients With Type 2 Diabetes, Journal of Isfahan Medical School (2012)
48. A Randomized Controlled Trial: Efficacy and Safety of Azithromycin, Ofloxacin, Bismuth, and Omeprazole Compared With Amoxicillin, Clarithromycin, Bismuth, and Omeprazole As Second-Line Therapy in Patients With Helicobacter Pylori Infection, Helicobacter (2010)
49. Genetic Diversity and Drug Resistance of Helicobacter Pylori Strains in Isfahan, Iran, Iranian Journal of Basic Medical Sciences (2008)
50. Evaluation of Apoptosis Induction Using Parp Cleavage on Gastric Adenocarcinoma and Fibroblast Cell Lines by Different Strains of Helicobacter Pylori, Pakistan Journal of Biological Sciences (2007)